大剂量氨溴索治疗重症肺炎疗效及可行性评价

Evaluation of Large Dose of Ambroxol in the Treatment of Severe Pneumonia and Feasibility

目的探讨大剂量氨溴索治疗重症肺炎的临床效果及可行性。方法选取2015年1月—2016年1月凉山彝族自治州第一人民医院收治的重症肺炎患者200例,平均分为观察组100例及对照组100例。对照组患者采用头孢哌酮舒巴坦钠治疗,观察组在此基础上联合大剂量氨溴索治疗。比较治疗后两组患者炎性指标[C反应蛋白(CRP)和血清钙素原(PCT)]、血氧饱和度(Sp O2)、住院时间、临床疗效及临床症状减轻时间(退热时间、咳嗽恢复时间、肺部湿啰音恢复时间)。结果观察组患者治疗后CRP水平、PCT水平均低于对照组,Sp O2高于对照组(P<0.05)。观察组患者住院时间短于对照组,临床疗效优于对照组(P<0.05)。观察组患者退热时间、咳嗽恢复时间、肺部湿啰音恢复时间均短于对照组(P<0.05)。结论大剂量氨溴索在治疗重症肺炎上疗效显著,能增加抗菌药疗效,保护患者肺组织。

Objective To investigate the clinical effect of large dose of ambroxol hydrochloride in the treatment of severe pneumonia and feasibility. Methods January 2015 to January 2016,200 cases of patients with severe pneumonia in the First People’s Hospital of Liangshan Yi Autonomous Prefecture,randomly divided into observation group（ 100 cases） and control group（ 100 cases）. The cefoperazone sulbactam sodium was used in the control group,the high dose ambroxol was used in the observation group based on control group. After treatment,the inflammatory index of（ CRP and PCT）,Sp O2,hospitalization time,clinical effect and symptoms relieve time（ cough fever time, recovery time, recovery time of pulmonary rales） were compared between the two groups. Results The levels of CRP and PCT in the observation group were lower than those in the control group,Sp O2 was higher than that in the control group（ P 〈 0. 05）. Hospitalization time in the observation group was shorter than that of the observation group,the clinical efficacy in the observation group was better than that of the control group（ P 〈 0. 05）. Cough fever time,recovery time,recovery time of pulmonary rales in the observation group were significantly shorter than that of the control group（ P 〈 0. 05）. Conclusion A significant effect of large dose of ambroxol hydrochloride in the treatment of severe pneumonia,it can increase the antibacterial efficacy,lung protection of patients.