无创正压通气治疗COPD急性发作80例临床研究

Clinical Research on Noninvasive Positive Pressure Ventilation in Treatment of 80 Cases of Patients with COPD Acute Attack

目的探究无创正压通气治疗COPD急性发作的临床效果。方法随机收集2015年3月—2016年3月该院收治的80例COPD急性发作患者进行详细研究,按奇偶数原则将上述患者分为两组,对照组(40例)患者接受慢阻肺常规治疗,观察组(40例)在对照组治疗基础上接受无创正压通气治疗,比较两组患者动脉血气分析指标、病死率、平均住院时间、气管插管率、并发症几率。结果 (1)治疗前两组患者Sa O2、Pa CO2、Pa O2等动脉血气分析指标差异无统计学意义(P>0.05);治疗后观察组Sa O2(88.8±8.2)%、Pa CO2(55.3±5.0)mm Hg、Pa O2(75.5±4.5)mm Hg指标显著优于对照组水平,组间差异有统计学意义(P<0.05)。(2)观察组患者病死率(2.5%)、平均住院时间(11.3±1.2)d、气管插管率(10.0%)显著低于对照组水平,组间差异有统计学意义(P<0.05)。(3)两组患者均未出现面部受损、误吸、排痰障碍等并发症。结论无创正压通气治疗COPD急性发作效果显著,值得临床推广。

Objective To study the clinical effect of noninvasive positive pressure ventilation in treatment of 80 cases of patients with COPD acute attack. Methods 80 cases of patients with COPD acute attack admitted and treated in our hospital from March 2015 to March 2016 were random selected and divided into two groups with 40 cases in each, the control group adopted the routine chronic obstructive pulmonary disease treatment, while the observation group adopted the noninvasive positive pressure ventilation treatment, and the arterial blood gas analysis indicators, death rate, average length of stay, endotracheal intubation rate and occurrence rate of complications were compared between the two groups. Results（1）Before treatment, the differences in the SaO2,PaCO2,PaO2 between the two groups had no statistical significance（P〉0.05）; after treatment, the Sa O2（88.8±8.2）%, Pa CO2（55.3±5.0）mm Hg, Pa O2（75.5±4.5）mm Hg in the observation group were obviously better than those in the control group, and the differences between the two groups had statistical significance（P 0.05）.（2） The death rate, average length of stay and endotracheal intubation rate in the observation group were respectively2.5%,（11.3±1.2）d and 10.0%, which were obviously better than those in the control group, and the differences between the two groups had statistical significance（ P 0. 05）.（3） There were no complications such as facial injury, aspiration and sputum drainage disorder. Conclusion The effect of noninvasive positive pressure ventilation in treatment of 80 cases of patients with COPD acute attack is obvious, which is worth clinical promotion.