氯吡格雷治疗不稳定型心绞痛的临床研究

Clinical Research on Clopidogrel in Treatment of Unstable Angina Pectoris

目的探讨氯吡格雷治疗不稳定型心绞痛的临床效果及价值。方法方便选取该院于2015年4月—2016年4月间收治的90例不稳定型心绞痛患者为研究对象,随机分为对照组和观察组,各45例。给予对照组常规治疗,给予观察组常规治疗基础上的氯吡格雷治疗,对比两种治疗模式的临床效果。结果观察组的治疗总有效率为95.56%,治疗后的心绞痛次数、纤维蛋白原、血小板指标分别为(2.1±1.2)次、(4.8±1.1)g/L、(161.0±66.0)×109/L,明显优于对照组,差异有统计学意义(P<0.05)。观察组治疗后的TC、TG、LDL-C、HDL-C水平分别为(2.7±0.6)、(0.6±0.1)、(1.7±0.3)、(1.8±0.4)mmol/L,均优于对照组,两组差异有统计学意义(P<0.05)。结论对不稳定型心绞痛患者实施常规治疗基础上的氯吡格雷治疗,疗效显著,值得推广和应用。

Objective To discuss the clinical effect and value of clopidogrel in treatment of unstable angina pectoris. Methods 90 cases of patients with unstable angina pectoris admitted and treated in our hospital from April 2015 to April 2016 were convenient selected as the research objects and randomly divided into two groups with 45 cases in each, the control group adopted the routine treatment, while the observation group adopted the clopidogrel treatment on the basis of the routine treatment, and the clinical effect of the two treatment methods was compared. Results The total treatment effective rate in the observation group was 95.56%, and the angina pectoris frequency, contractinogen and platelet indexes were respectively（2.1±1.2）,（4.8±1.1）g/L,（161.0±66.0）×109/L, which were obviously better than those in the control group, and the differences had statistical significance（P〈0.05）, and the TC, TG, LDL-C and HDL-C levels after treatment in the observation group were respectively（2.7±0.6）,（0.6±0.1）,（1.7±0.3）,（1.8±0.4）mmol/L,Convenient, which were better than those in the control group, and the differences between the two groups had statistical significance（ P 0.05）. Conclusion The curative effect of the clopidogrel treatment on the basis of the routine treatment for patients with unstable angina pectoris is obvious,which is worth promotion and application.