治疗创伤后应激障碍的新靶点:内源性大麻素系统

Novel therapeutic targets for post-traumatic stress disorder:endocannabinoid system

负面情绪,如焦虑和恐惧会使个体对潜在的危险和伤害刺激保持警觉,从而提高生存能力,但是当个体对这些潜在的危险过度应答时,便会对身心功能造成伤害。创伤后应激障碍（post-traumatic stress disorder,PTSD）是一种个体因为经历或目睹对生命具有威胁性的事件或严重的创伤,从而导致系列精神症状并出现长期持续的精神障碍,是对异乎寻常的威胁性、灾难性事件的延迟和持久的反应。

Post-traumatic stress disorder （PTSD） is a kind of mental disorder that usually occurs after life- threatening and strong mental traumas. Clinical studies showed that the PTSD patients are 3 times more likely to have can-nabis as compared with the healthy people. The use of cannabinoids has a close relationship with the occurrence and clini-cal manifestations of PTSD. Experimental studies revealed that endocannabinoid （eCB） signal alterations in animal models of PTSD influenced fear memory of the animals, suggesting a close correlation between the eCB system and the pathogenesis of PTSD. Given that the eCB system was reported to regulate affective states and participate in memory consolidation, re-trieval and extinction, targeting the eCB system may improve the emotional and cognitive features of PTSD, thereby holding out great promise for the development of novel approaches for clinical treatment of PTSD.