成纤维细胞分化为肌成纤维细胞的调控机制

Mechanism of regulating the differentiation of cardiac fibroblasts into myofibroblasts

心脏重塑的关键病理特征和主要形成原因是心肌细胞肥大和心肌纤维化。研究证明在心肌纤维化中成纤维细胞和肌成纤维细胞是主要作用细胞,其中肌成纤维细胞的来源广泛,它的形成通常需要经过两个阶段的转化。然而有很多传导途径及相关的调节因子参与了这一系列复杂的转化过程,包括转化生长因子-β细胞的信号转导,血管紧张素Ⅱ信号转导,内皮素1信号转导,瞬时受体电位通道及机械转录偶联等。

Cardiomyocyte hypertrophy and cardiac fibrosis are the critical pathological features and major causes of cardiac remodeling. Previous studies have proven that fibroblasts and myofibroblasts play a major role during the process of cardiac remodeling. Myofibroblasts are extensively available and constantly experience two stages of transformation. However,multiple transduction pathways and relevant regulatory factors participate in the complex transformation process including TGF-β signaling transduction,angiotensin Ⅱ signaling,endothelin 1 signaling,transient receptor potential channels and mechanical transcriptional coupling,etc.