摘要
肝窦内皮细胞(liver sinusoidal endothelial cells,LSECs)作为肝脏中比例最高的非实质细胞,其窗孔结构和高内吞清除能力在肝脏生理病理过程中发挥不可或缺的作用。LSECs主要通过发挥抗炎、内吞、分泌促血管生成信号分子和维持HSCs表型等作用,参与调控非酒精性脂肪肝病(nonalcoholic fatty liver disease,NAFLD)、酒精性脂肪肝(alcoholic fatty liver,AFL)、肝细胞性肝癌(hepatocellular carcinoma,HCC)、肝再生、肝纤维化等肝脏病理过程。该文就LSECs正常生理功能及其在各种病理状态下发挥的不同作用作一综述,旨在通过靶向LSECs为治疗肝脏疾病提供新的观点。
Liver sinusoidal endothelial cells (LSECs) are the highest proportion of liver non-parenchymal cells with fenestrae structure and high endocytic ability maintaining liver homeostasis and playing an indispensable role in the physiology and patholo-gy of the liver.LSECs are involved in the regulation of patholog-ical process in nonalcoholic fatty liver disease(NAFLD),alco-holic fatty liver(AFL),hepatocellular carcinoma(HCC),liverregeneration and liver fibrosis mainly via antiinflammation,endocytosis,secretion of angiocrine signals and maintaining thequiescence phenotype of HSCs.This review highlights the physiological function of LSECs and the different roles in different pathological conditions,which aims to provide a new perspectivefor the treatment of liver diseases through targeting LSECs.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2017年第2期149-153,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No81270514,31401210,31571455)
江苏省自然科学基金青年基金(NoBK20140955)
江苏省高校自然科学研究面上项目(No14KJB310011)
2013年江苏高校优秀科技创新团队计划
江苏高校优势学科建设工程资助项目(Noysxk-2010)
南京市医学科技发展项目(NoYKK14143)