TORCH联合感染对幼儿脑性瘫痪严重程度的影响

The Effect of Combined Infection of TORCH on Severity of Juvenile Cerebral Palsy

目的:探讨TORCH感染对幼儿脑性瘫痪严重程度的影响,为预测预后提供依据。方法:对随机入选的97例脑性瘫痪患儿应用酶联免疫吸附试验(ELISA)检测血清TORCHIg-G抗体。结果:(1)97例脑性瘫痪患儿的TORCH感染率高达80.41%,TOX、RV、CMV、HSV感染率依次为4.12%、31.96%、62.89%、24.74%。(2)对入选患儿按TORCH检测结果分为阴性组(20人)、单项感染组(44人)、多联合感染组(33人)。阴性组中轻度脑性瘫痪者2人,中度者8人,重度者10人;单项感染组中轻度、中度、重度度者分别为3人、23人、18人;联合感染组中轻度、中度、重度度者分别为5人、17人、11人。卡方检验结果显示,P>0.05。结论:脑性瘫痪幼儿的TORCH感染率高,以CMV感染最常见,其次为RV;TORCH的联合感染对脑性瘫痪病情严重程度无显著影响。

Objective ： To investigate the influence of co- infection of TORCH on the severity of juvenile CP（ cerebral palsy）,so as to offer basis for prognosis prediction of juvenile CP. Methods： The juveniles aged from 1- 2years old with CP（ n = 97） were examined by TORCH- Ig G test. Result： 1. The infection rate of TORCH was 80. 41% in 97 cases. The infective rate of TORCH in TOX,RV,CMV,HSV were 4. 12%,31. 96%,62. 89% and 24. 74% respectively. 2. The infantile CP of 97 cases were divided to three groups：negative group（ n = 20）,single infection group（ n = 44）,combined infection group（ 33） according to the results of TORCH- Ig G.There were mild CP（ n = 2）,moderate CP（ n = 8）,severe CP（ n = 10） in negative group; mild CP（ n = 3）,moderate CP（ n = 23）,severe CP（ n = 18） in single group; mild CP（ n = 5）,moderate CP（ n = 17）,severe CP（ n = 11） in combined group. With chi-square test,the results showed P 〉 0. 05. Conclusions： 1. The rate of infection of TORCH in juvenile CP is high. The CMV infection was the highest,secondly it is RV. 2. Combined infection of TORCH had no significant effect on severity of CP.