方酸菁染料在生物检测中的研究进展

Research Progress on Squaraine Dyes in Bioassay Technology

方酸菁是一种新型的近红外有机染料,由于其特殊的D-A-D结构,在可见-近红外区域有强烈的吸收和荧光发射,因而越来越多地被应用在生物检测中。综述了近年来方酸菁染料在生物检测技术中的发展和应用,也介绍了方酸菁探针的荧光成像技术在蛋白质标记和肿瘤标记与诊断中的应用,并展望了该领域的发展前景。

Squarylium is a new near-infrared organic dye.Due to its special structure Donor-Accept-Donor,squaraine dyes in the visible-near infrared region have a strong absorption and fluorescence emission,which have been used increasingly in biological fluorescence imaging.This article discussed the development and application of squaraine dyes in biological fluorescence imaging.The squarylium probe fluorescence imaging as markers in protein and tumoris was also introduced,as well as diagnosis drugs in tumor.Moreover,the further development prospect in this field is prospected.