超敏肌钙蛋白Ⅰ在扩张型心肌病HF失代偿期的临床价值

Clinical Value of hs-cTnI in HF in Decompensated Patients with Dilated Cardiomyopathy

目的:探讨扩张型心肌病(DCM)患者心力衰竭(HF)失代偿期超敏肌钙蛋白I(hs-cTnI)浓度与HF严重程度及预后的关系。方法:HF失代偿期住院的DCM患者263例,按hs-cTnI水平分为正常组(A组,143例)和升高组(B组,120例)。分析两组患者入院时的一般资料、检查及出院后12个月内的终点事件。结果:B组患者脑利钠肽前体(NT-proBNP)比A组患者入院时更高(P<0.05)、射血分数更低(P<0.05)、左室舒张末期内径更大(P<0.05)、NYHA分级达Ⅲ、Ⅳ级的比率更高(P<0.05);B组患者3、6、12个月的终点事件发生率明显高于A组患者(P<0.05)。结论:DCM患者HF失代偿期hs-TnI浓度升高提示患者HF程度更严重、患者12个月内终点事件的发生率更高,对12个月内终点事件发生有预测价值。

Objective：To investigate the relationship between highy sensitive cardiac troponinl（hs-cTnI） concentration and HF severity and prognosis in patients with dilated cardiomyopathy（DCM） and heart failure（HF）.Methods：263 cases of DCM who were hospitalized in HF were divided into normal group（group A,143 cases） and elevated group（120 cases in group B） according to the hs-cTnl level.Analysis of the two groups of patients at the time of admission to the general information,check and the end of the 12 months after discharge.Results：Brain natriuretic peptide（NT proBNP） in group B was Higher than that of A group of patients admitted to hospital patients（P〈0.05）,shoot ejection fraction lower（P〈0.05）,left ventricular end diastolic diameter greater（P〈0.05）,NYHA class of Ⅲ,Ⅳ ratio higher（P〈0.05）;patients in group B and 3,6,12 months of endpoint occurrence rate was significantly higher than that of the patients in group A（P〈0.05）.Conclusion：DCM patients with HF decompensation HS Tnl concentration elevated in patients with HF,with 12 months endpoint rate high,to 12 months in the end event prediction value.