多发性硬化患者心率变异性变化及其临床意义

Heart Rate Variability Changes in Patients with Multiple Sclerosis and Its Clinical Significance

目的:探讨多发性硬化患者心率变异性变化及其临床意义。方法:选取40例多发性硬化且无心血管自主神经功能障碍患者为观察组和30例健康志愿者为对照组。比较两组心率变异性变化情况。统计两组随访1年的心血管自主神经功能障碍发生情况,比较观察组不同心血管自主神经功能障碍发生情况患者心率变异性,并采用ROC曲线分析多发性硬化患者心率变异性对其心血管自主神经功能障碍的预测价值。结果:观察组与对照组比较6h和24h的SDNN、SDANN、RMSSD等心率变异性指标差异有统计学意义(P<0.05)。多发性硬化患者中发生心血管自主神经功能障碍的例数和心血管自主神经功能障碍发生率高于对照组的6.67%(P<0.05)。合并心血管自主神经功能障碍的多发性硬化患者各心率变异性指标均低于无血管自主神经功能障碍的多发性硬化患者(P<0.05)。结论:多发性硬化患者心率变异性降低且对其心血管自主神经功能障碍发生的价值良好,心率变异性指标可作为多发性硬化患者心血管自主神经功能障碍早期诊断参考指标之一。

Objective：To investigate the change of heart rate variability in patients with multiple sclerosis and its clinical significance.Methods：40 patients with multiple sclerosis and no cardiovascular autonomic dysfunction were selected as observation group and 30 healthy volunteers as control group.The changes of heart rate variability in the two groups were compared.The occurrence of statistics of the two groups were followed up for 1 years of cardiovascular autonomic nerve dysfunction was observed in different cardiovascular autonomic dysfunction in patients with heart rate variability,and analyze the predictive value of multiple sclerosis patients with heart rate variability on the cardiovascular autonomic nerve dysfunction by ROC curve.Results：Compared with the control group,the difference of SDNN,SDANN,RMSSD and heart rate variability between the observation group and the control group was statistically significant（6h）（P 0.05）（24h）.The incidence of cardiovascular autonomic dysfunction and the incidence of cardiovascular autonomic dysfunction in patients with multiple sclerosis were 6.67% higher than those in control group（P 0.05）.The rate of heart rate variability in patients with multiple sclerosis with cardiovascular autonomic dysfunction was lower than that in patients with multiple sclerosis（P 0.05） without autonomic dysfunction.Conclusion：Multiple sclerosis patients with decreased heart rate variability and good for the occurrence of cardiovascular autonomic nerve dysfunction,heart rate variability index in patients with multiple sclerosis as a cardiovascular autonomic dysfunction early diagnosis index of reference.