高尿酸血症与缺血性脑卒中复发的相关性分析

Analysis of Correlation between the Hyperuricemia and Recurrence of Cerebral Arterial Thrombosis

目的观察高尿酸血症与缺血性脑卒中复发的相关性。方法选取该院2011年1月—2013年10月收治的首发缺血性脑卒中患者共230例,出院后随访时间满2年。按入院时尿酸水平分为高尿酸组65例和正常尿酸组165例。两组均禁食8 h以上,于入院次日清晨取空腹静脉血,分离血清后做血尿酸测定。应用前瞻性队列研究,对入选者采用门诊、电话、微信等方式随访,半年左右随访1次,累计随访时间2年,记录缺血性脑卒中复发情况。结果 230例首发缺血性脑卒中入选患者中在2年随访期间内,共发生缺血性脑卒中45例,缺血性脑卒中的复发率为19.6%,其中在65例高尿酸组发生19例,复发率为29.2%,165例正常尿酸组发生26例,复发率为15.8%,高尿酸组缺血性脑卒中复发率高于正常尿酸组,两组间缺血性脑卒中复发率比较,差异有统计学意义(P<0.05)。结论高水平血尿酸增加了缺血性脑卒中复发的风险,降低及控制高尿酸血症对缺血性脑卒中的二级预防有非常重要的积极作用。

Objective To observe the correlation between the hyperuricemia and recurrence of cerebral arterial thrombosis. Methods 230 cases of patients with cerebral arterial thrombosis admitted and treated in our hospital from January 2011 to October 2013 were se-lected and followed up for 2 years after discharge, and divided into the hyperuricemia group with 65 cases and normal uric acid group with 165 cases, both groups were fasting more than 8 hours and the serum was isolated for blood uric acid measurement, and the pa-tients were followed up by outpatient, telephone and wechat for two years once half a year, and the recurrence of cerebral arterial thrombosis was recorded. Results In the 230 cases, there were 45 cases with cerebral arterial thrombosis, and the recurrence rate was 19.6%,and 19 cases with hyperuricemia and 26 cases with normal uric acid,the recurrence rate in the hyperuricemia group was high- er than that in the normal uric acid group （29.2% vs 15.8%）, and the difference had statistical significance （P〈0.05）. Conclusion The high-level blood uric acid increases the recurrence risk of cerebral arterial thrombosis, which is of very important positive significance to reducing and controlling the second prevention of hyperuricemia to the cerebral arterial thrombosis;