血液透析对慢性肾功能衰竭患者血清脂蛋白的影响

Influence of blood dialysis on serum lipoprotein in patients with chronic renal failure

目的:探讨血液透析对慢性肾功能衰竭(CRF)患者血清脂蛋白的影响及意义。方法:将行血液透析的CRF患者35例设为观察组,选择同期健康人35例设为对照组,观察血液透析对患者血清脂蛋白的影响。结果:透析前观察组高密度脂蛋白胆固醇(HDL-C)、白蛋白(Alb)明显低于对照组,血清脂蛋白(a)[Lp(a)]、尿素(Urea)、肌酐(Cr)、三酰甘油(TG)、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)水平明显高于对照组,两组比较差异具有统计学意义(P<0.05)。观察组透析前载脂蛋白A(Apo A)及载脂蛋白B(Apo B)水平与对照组比较差异无统计学意义(P>0.05)。观察组透析后Lp(a)、Urea及Cr水平明显低于透析前,两者比较差异具有统计学意义(P<0.05)。观察组透析后TG、TC、HDL-C、LDL-C、Apo A、Apo B及Alb与透析前比较差异无统计学意义(P>0.05)。结论:血液透析对CRF患者血清脂蛋白的影响较大,需检测血脂水平,预防心脑血管事件。

Objective To investigate the influence of blood dialysis on serum lipoprotein in patients with chronic renal failure.Method 35 cases with CRF were set into the observation group,and 35 cases with health crowd were set into the control group at the same time.The influence of blood dialysis on serum lipoprotein in patients with chronic renal failure were evaluated.Results Before dialysis,the HDL-C,Alb level of the observation group was significantly lower than those of the control group,Lp（ a）,Urea,Cr,TG,TC and LDL-C level of the observation group was significantly higher than those of the control group,and there was significant difference（ P〈0.05）.There was no significant difference on Apo A and Apo B between the observation group and the control group（ P〉0.05）.After dialysis,the Lp（ a） 、Urea and Cr level of the observation group was significantly lower than those before dialysis,and there was significant difference（ P〈0.05）.There was no significant difference on TG、TC、HDL-C、LDL-C、Apo A、Apo B and Alb of the observation group between After dialysis,and before dialysis（ P〉0.05）.Conclusion The influence of blood dialysis on serum lipoprotein in patients with chronic renal failure is obvious,so detection of blood lipid is necessary to prevention of cardiovascular events.