半剂量甘露醇治疗脑出血及对尿微量蛋白的影响

Half dose of mannitol in treatment of cerebral hemorrhage and effect on urine protein

目的:探讨不同剂量的甘露醇治疗脑出血患者的临床效果及对尿微量蛋白的影响。方法:将脑出血患者120例随机分为观察组和对照组,对照组给予全剂量甘露醇治疗,观察组给予半剂量甘露醇治疗,观察两组效果及肾毒性。结果:观察组总有效率与对照组比较,差异无统计学意义(P>0.05)。治疗后观察组Uβ2-MG、UIAb及UIg G水平明显低于对照组,两者比较,差异具有统计学意义(P<0.05)。治疗后观察组血肌酐及尿素氮水平水平明显低于对照组,两者比较差异具有统计学意义(P<0.05)。结论:半剂量的甘露醇治疗脑出血临床效果明确,且肾毒性作用弱,值得应用。

Objective To investigate the effect about half dose of mannitol in treatment of cerebral hemorrhage and effect on urine protein.Method 120 cases with cerebral hemorrhage were randomly divided into the observation group and the control group.The control group was given the full dose of mannitol treatment,and the observation group was given the half dose of mannitol.The effect and renal toxicity were evaluated.Results There was no significant difference on total efficiency between the observation group and the control group（ P〈0.05）.After treatment,the U beta 2-MG,UIAb and UIg G level of the observation group were significantly lower than those of the control group,and there was significant difference（ P〉0.05）.After treatment,the blood creatinine and blood urea nitrogen levels of the observation group were significantly lower than those of the control group,and there was significant difference（ P〈0.05）.Conclusion The clinical effect of half dose mannitol in treatment of cerebral hemorrhage is obvious,and the renal toxicity is weak,so it is worthy of application..