注射用骨肽联合利塞膦酸钠治疗腰椎骨折患者手术后骨组织修复的临床观察

The clinical effect of ossotide injection and risedronate for the treatment of lumbar bone tissue repair after surgery for fracture

目的探讨注射用骨肽联合利塞膦酸钠治疗腰椎骨折患者手术后骨组织修复的临床疗效。方法选择86例行腰椎手术的患者,并随机分为观察组和对照组,各43例。对照组患者给予利塞膦酸钠片,观察组患者在应用利塞膦酸钠片的基础上,给予注射用骨肽。于术前和术后1个月,测定两组患者的血清骨性标志物水平:骨碱性磷酸酶(BALP)、骨钙素(BGP)、I型前胶原羧基端肽(PICP)、总骨I型前胶原氨基端延长肽(Total-PINP)、I型胶原羧基端肽β特殊序列(β-CTX)。术前和术后3个月测量腰椎手术部位骨密度。评定两组患者骨愈合的疗效。计算并比较两组患者治疗的总有效率。结果观察组的总有效率显著高于对照组的总有效率。两组患者经治疗后的BALP,BGP和PICP水平均显著高于治疗前,Total-PINP和β-CTX水平均显著低于治疗前,观察组治疗后的BALP、BGP和PICP水平均显著高于对照组,Total-PINP和β-CTX水平均显著低于对照组。治疗后两组患者的骨密度水平均显著高于治疗前,且观察组的骨密度水平显著高于对照组。上述差异均有统计学意义(P<0.05)。结论注射用骨肽联合利塞膦酸钠能显著促进腰椎骨折患者手术后骨组织修复,调节骨性标志物水平,提高患者的骨密度。

Objective To study clinical effect of ossotide injection and risedronate for the treatment of lumbar bone tissue repair after surgery for fracture. Methods 86 patients with lumbar spine surgery were selected and randomly divided into observation group and control group,each with 43 cases. The control group were treated with risedronate sodium tablets,the patients in observation group were treated with ossotide injection based on the application of risedronate sodium tablets. The levels of serum markers in the serum of the two groups were measured before and after operation. Bone alkaline phosphatase（BALP）,osteocalcin（BGP）,procollagen type I carboxy terminal peptide（PICP）,total bone procollagen amino terminal peptide（Total-PINP）,type I collagen carboxy terminal peptide sequence specific beta（β-CTX） were detected. Bone mineral density of lumbar spine was measured before and 3 months after operation. The curative effect was evaluated according to the fracture healing time. The total effective rates of the two groups were calculated and compared. Results The total effective rate of the observation group was significantly higher than that of the control group. After treatment,the levels of BALP,BGP and PICP in the two groups were significantly higher than those before treatment,and the levels of Total-PINP and β-CTX were significantly lower than those before treatment. After treatment,the levels of BALP,BGP and PICP in the observation group were significantly higher than those in the control group,and the levels of Total-PINP and β-CTX were significantly lower than those of the control group. After treatment,the bone mineral density of the two groups were significantly higher than before treatment,and the bone mineral density of the observation group was significantly higher than that of the control group. Conclusion Ossotide Injection and risedronate can significantly promote the repair of bone tissue after operation in patients with lumbar fracture,regulating bone markers,increase bone mineral density.