艾灸治疗膝骨关节炎的系统性评价及Meta分析

Moxibustion for the treatment of patients with keen osteoarthritis. A systematic review and meta analysis

目的探讨艾灸治疗膝骨关节炎患者的干预效果。方法通过检索Pubmed﹑Embase﹑Cochrane Central Register of Controlled Trials,CINAHL,中国期刊全文数据库(CNKI)和万方数据库等资源,收集艾灸干预对于膝骨关节炎患者疗效的随机对照试验,并进行文献质量评价和数据提取。整个的结局指标包括了疼痛评分量表(Numerical Rating Scale,NRS),健康调查简易问卷(the MOS item short from health survey,SF-36)生活质量评分,骨性关节炎总评分(Western Ontario and Mc Master Universities Questionnaire,WOMAC)。结果最终纳入7篇文献,文献证据质量大多为中等。Meta分析结果显示,与对照组相比,艾灸治疗干预可以有效改善膝骨关节炎患者NRS疼痛评分和SF-36生活质量量表的试验结果,差异有统计学意义(P<0.05)。此外,艾灸治疗干预具有改善膝骨关节炎患者WOMAC评分的趋势,但是差异并无统计学意义(P=0.06)(P<0.05)。结论艾灸干预可以让膝骨关节炎患者获益。但是未来研究中仍然要克服相应的方法学缺陷。

Objective To explore effects of moxibustion intervention for the treatment of patients with osteoarthritis by Methods Electronic databases, including Pubmed, Embase, Cochrane Central Register of Controlled Trials, CINAHL, CNKI and wanfang, were used to search. Randomized controlled trials （RCTs） which met the inclusion criteria were collected. After quality of the RCTs was appraised and the data was extracted, meta - analysis was used in Numerical Rating Scale, SF - 36 QoL scale, Western Ontario and McMaster Universities Ques-tionnaire, WOMAC. All data were analyzed with Revman5. 3.5. Results Seven RCTs were included,the quality of RCTs were moderate. Meta -analysis showed that compared with the control group, moxibustion intervention group had significant improvements in NRS, SF - 36 QoL （ P 〈0. 01）. While no significant difference was found in terms of WOMAC. Conclusion Moxibustion intervention has a positive role in improving pa-tients＂ osteoarthritis. But in the future research, it still has to overcome the corresponding methodological defects.