两种免疫治疗方法治疗封闭抗体阴性复发性流产的对照研究

A comparative study of two immune methods in the treatment of pregnant women with negative blocking antibody and recurrent spontaneous abortion

目的:比较两种免疫治疗方法对封闭抗体阴性复发性流产的治疗效果。方法:选择确诊原因不明性复发性流产患者封闭抗体检测阴性的患者270例,随机分为淋巴细胞免疫治疗组(162例)和静脉滴注免疫球蛋白组(108例),分别采用淋巴细胞主动免疫治疗和小剂量静脉注射免疫球蛋白被动免疫治疗,统计两组的妊娠成功率。结果:主动免疫治疗组成功妊娠135例(83.3%),被动免疫治疗组成功妊娠97例(90.0%)(P>0.05),不良反应两组比较,主动免疫组发生率为7.4%,被动免疫组被0.9%(P<0.05)。结论:对封闭抗体阴性复发性流产孕妇主动免疫治疗与被动免疫治疗效果相当,但是被动免疫治疗更为简单安全。

Objective：Compare two methods of immunotherapy for the therapeutic effect of closed antibody negative recurrent miscarriage. Methods ： Choose diagnosis unknown cause sexual closed negative antibody detection of recurrent abortion patients 270 cases, were randomly divided into the lymphocyte immune treatment group （162 cases） and intravenous drip immunoglobu-in group （108 cases） , lymphocytes were used respectively to active immunotherapy and small dose of intravenous immunoglob-ulin passive immunotherapy, statistics of two groups of pregnancy success rate. Results：The active immune treatment group, 135 cases of successful pregnancy （83. 3%）,passive immunity treatment group, 97 cases of successful pregnancy （90. 0 % ） （P〉0. 05）,adverse reactions in the two groups,the incidence of active immunization group was 7. 4 % ,passive immunization group was 0. 9% （P 〈0. 05）. Conclusion： The curative effects of the two treatment methods with negative blocking antibody and recurrent spontaneous abortion are about the same, but the low dose IVIG treatment was more simple and safety.