巴氯芬治疗恶性肿瘤放化疗患者顽固性呃逆的疗效观察

Observe the curative effect of baclofen on malignant tumors radiotherapy and chemotherapy patients with intractable hiccup

目的:观察巴氯芬治疗恶性肿瘤患者放化疗后出现的顽固性呃逆的临床疗效及不良反应。方法:收集2015年03月至2016年03月恶性肿瘤患者放化疗后出现的顽固性呃逆病例共计45例。按照治疗方式的不同,随机分为研究组和对照组,研究组21例,对照组24例。研究组予以巴氯芬,对照组予以氯丙嗪、异丙嗪、山莨胆碱、地西泮、胃复安及中医针灸等治疗,用药5~7天后评价两组患者治疗效果。结果:研究组的中位起效时间为2d,对照组的中位起效时间为4d。研究组治愈率高于对照组(P<0.05);总有效率(治愈率+显效率+有效率)比较,研究组总有效率明显高于对照组(P<0.01)。研究组治疗后不良反应总发生率低于对照组(P<0.05)。研究组治疗后乏力、嗜睡发生率低于对照组(P<0.05)。研究组患者治疗后低血压发生率低于对照组(P<0.05)。结论:巴氯芬对恶性肿瘤放化疗患者顽固性呃逆安全、有效,不良反应相对较轻、较少,是治疗呃逆较为有效的方法之一,值得临床进一步推广应用。

Objective：To observe the curative effect and adverse reactions of baclofen on malignant tumors radiotherapy and chemotherapy patients with intractable hiccup.Methods：We collected the data of 45 cases of malignant tumors radiotherapy and chemotherapy patients with intractable hiccup in our hospital were enrolled from March 2015 to March 2016.According to the different treatment methods,they were divided into 2 groups randomly,the experiment group were 21 cases,the control group were 24 cases.The experiment group were treated with baclofen,the control group were treated with chlorpromazine,promethazine,mountain buttercup choline,diazepam,metoclopramide and acupuncture,evaluate the therapeutic effect of two groups patients 5 to 7 days later.Results：The median onset time of the experiment group were 2d,the control group median onset time were 4d.The cure rate of the experiment group was higher than the control group（P〈0.05）;the total effective rate（cure rate＋explicit efficiency＋effective rate）of the experiment group compared with the control group was significantly higher（P〈0.01）than the control group.The total incidence rate of adverse reactions after treatment in the experiment group was lower than that in the control group（P〈0.05）.The incidence of fatigue and sleepiness in the experiment group was lower than that in the control group（P〈0.05）.The incidence of hypotension in the experiment group was lower than that in the control group（P〈0.05）.There was no significant difference in the incidence of any other adverse reactions between the two groups（P〉0.05）.Conclusion： Baclofen on malignant tumor radiotherapy and chemotherapy patients with intractable hiccup is safe and effective,adverse reactions are relatively mild and less,which is an effective treatment of hiccup and worths further clinical application.