血清白细胞介素-6与冠状动脉支架内再狭窄的相关性分析

Correlation between serum interleukin-6 and coronary in-stent restenosis

目的探讨血清白细胞介素（IL）-6与冠状动脉支架内再狭窄（ISR）的相关性。方法根据经皮冠状动脉介入（PCI）术后复查冠状动脉造影结果，将74例冠心病患者分为ISR组10例和非ISR组64例，采用光学相干断层成像（OCT）定量分析冠状动脉支架内膜组织最大覆盖厚度、最狭窄处血管管腔面积（LA）、最狭窄处支架面积（SA）等，计算支架的内膜组织覆盖面积即截面积丢失（NA）和NA百分比，检测所有患者术前1天和术后24小时、7天、6个月的血清IL-6水平并进行比较。结果ISR组内膜组织最大覆盖厚度、NA及NA百分比均明显高于非ISR组，LA明显低于ISR组（P〈0．01）；而两组间SA比较，差异无统计学意义（P〉0．05）。术后7天ISR组的IL-6水平显著高于非ISR组（P〈0．05）。ISR组术后24小时、7天IL-6水平较术前1天均显著升高（P〈0．05），而术后6个月无明显变化（P〉0．05）；非ISR组仅术后24小时IL-6水平较术前1天显著升高（P〈0．05），而术后7天、6个月无明显变化（P〉0．05）。ISR组患者术后平均7．5个月的NA百分比与术后7天血清IL-6水平呈显著正相关（r=0．637，P〈0．01）。结论血清IL-6水平可作为预测PCI术后ISR的参考指标之一。

Objective To explore the correlation between serum interleukin（IL）-6 and coronary in-stent restenosis（ISR）. Methods According to the results of coronary angiography after percutaneous coronary intervention（PCI） ,74 patients of coronary heart disease were divided into ISR group（ 10 cases） and non-ISR group （64 cases）. The maximal neointimal hyperplasia thickness, the minimal lumen area （LA） and stem area（SA） in the most narrow site were quantitatively analysed by optical coherence tomography（OCT） ,and the neointimal coverage area（NA） and NA percentage were calculated respectively. The serum levels of IL-6 1 day before PCI and 24 hours, 7 days, 6 months after PCI were detected and compared between the two groups. Results The maximal neointimal hyperplasia thickness, NA and NA percentage of the ISR group were higher than the non-ISR group and LA was lower than it （ P 〈 0.01 ） , but SA between the two group was not different significantly（ P 〉 0.05 ）. The serum level of IL-6 in ISR group 7 days after PCI was significantly higher than non-lSR group（ P 〈 0.05 ）, The serum level of IL-6 in ISR group 24 hours and 7 days after PCI increased significantly than that of 1 day before PCI（ P 〈 0.05 ）, but 6 months after PCI did not change significantly （ P 〉 0.05 ）. The serum level of IL-6 in non-ISR group 24 hours after PCI increased significantly than that of 1 day before PCI （ P 〈 0.05 ）, but those of 7 days and 6 months after PCI did not change significantly（ P 〉 0.05 ）. NA percentage on average of 7.5 months after PCI was positively correlated with the serum leve of IL-6 7 days after PCI（ r = 0. 637, P 〈 0.01 ）. Conclusion The serum level of IL-6 can be one of the indicators to predict ISR after PCI.