甲基强的松龙冲击治疗急性脊髓炎的临床效果分析

Analysis of clinical effect of methylprednisolone pulse therapy in acute myelitis

目的分析甲基强的松龙冲击治疗急性脊髓炎的临床效果。方法 70例急性脊髓炎患者为研究对象,采用随机分组法将患者分为观察组和对照组,各35例。对照组给予地塞米松及泼尼松治疗,观察组给予甲基强的松龙冲击治疗,对比两组治疗效果与神经功能恢复时间。结果观察组总有效率97.1%明显高于对照组80.0%,差异具有统计学意义(P<0.05)。观察组肌力改善≥2级时间为(10.25±4.28)d、排尿恢复时间为(7.21±3.54)d、自动下地行走时间为(16.28±4.40)d,均短于对照组的(23.54±7.54)、(10.28±3.24)、(22.75±7.35)d,差异均具有统计学意义(P<0.05)。结论甲基强的松龙冲击治疗急性脊髓炎,临床治疗安全可靠,治疗效果明显,值得在临床上进行应用。

Objective To analyze the clinical effect of methylprednisolone pulse therapy in acute myelitis. Methods A total of 70 acute myelitis patients as study subjects were randomly divided into experimental group and control group, with 35 cases in each group. The control group received dexamethasone and prednisone for treatment, and the observation group received methylprednisolone pulse therapy. Comparison were made on treatment effect and neural functional recovery time in two groups. Results The observation group had higher total effective rate as 97.1% than 80.0% in the control group, and the difference had statistical significance（P〈0.05）. The observation group had time of myodynamia improvement ≥ grade 2 as（10.25±4.28） d, urination recovery time as（7.21±3.54） d, automatic walking time as（16.28±4.40） d, which were all shorter than（23.54±7.54）,（10.28±3.24） and（22.75±7.35） d in the control group, and their difference had statistical significance（P〈0.05）. Conclusion Methylprednisolone pulse therapy is safe and reliable with remarkable treatment effect in acute myelitis, and it is worth clinical application.