针灸配合糖皮质激素对重症肌无力患者免疫球蛋白及补体的作用探讨

Investigation of effect by acupuncture and moxibustion combined with glucocorticoid for immunoglobulin and complement in myasthenia gravis patients

目的分析对重症肌无力患者实施针灸配合糖皮质激素治疗后,对免疫球蛋白和补体的作用。方法 60例重症肌无力患者,将其随机分为对照组和观察组,各30例。对照组实施糖皮质激素治疗,观察组在对照组基础上实施针灸治疗。比较两组患者的临床疗效、免疫球蛋白G3(IgG3)、IgG1以及补体C3水平。结果观察组患者治疗有效率为96.67%(29/30),对照组为93.33%(28/30),比较差异无统计学意义(χ~2=0.3509,P>0.05)。观察组补体C3水平为(1.29±0.13)g/L,明显高于对照组的(1.08±0.05)g/L,差异有统计学意义(t=8.2581,P=0.0000<0.05)。观察组免疫球蛋白IgG3水平为(0.65±0.21)g/L,明显低于对照组的(0.91±0.15)g/L,差异有统计学意义(t=5.5182,P=0.0000<0.05)。观察组免疫球蛋白IgG1水平为(6.85±1.21)g/L,明显高于对照组的(5.72±1.15)g/L,差异有统计学意义(t=3.7077,P=0.0005<0.05)。结论对重症肌无力患者治疗时,在使用糖皮质激素治疗的基础上应用针灸配合治疗,可在起到较好治疗效果的前提下对其免疫球蛋白和补体起到更好的改进效果。

Objective To analyze effect by acupuncture and moxibustion combined with glucocorticoid for immunoglobulin and complement in myasthenia gravis patients. Methods A total of 60 myasthenia gravis patients were randomly divided into control group and observation group, with 30 cases in each group. The control group received glucocorticoid for treatment, and the observation group received additional acupuncture and moxibustion to glucocorticoid in the control group for treatment. Comparison was made on clinical effect, immune globulin G3（IgG3）, IgG1 and complement C3 levels between the two groups. Results The observation group had effective rate in treatment as 96.67%（29/30）, which was 93.33%（28/30） in the control group, and their difference had no statistical significance（χ^2=0.3509, P〉0.05）. The observation group had obviously higher complement C3 as（1.29±0.13） g/L than（1.08±0.05） g/L in the control group, and the difference had statistical significance（t=8.2581, P=0.00000.05）. The observation group had much lower IgG3 level as（0.65±0.21） g/L than（0.91±0.15） g/L in the control group, and the difference had statistical significance（t=5.5182, P=0.00000.05）. The observation group had much higher IgG1 level as（6.85±1.21） g/L than（5.72±1.15） g/L in the control group, and the difference had statistical significance（t=3.7077, P=0.00050.05）. Conclusion In treating myasthenia gravis patients, implement of acupuncture and moxibustion on the basis of glucocorticoid can provide excellent curative effect, as well as imporve immunoglobulin and complement in patients.