两种蓝光照射方式治疗新生儿黄疸的疗效评价

Evaluation on curative effect of two blue light irradiation methods in the treatment of neonatal jaundice

目的探索两种不同的蓝光照射方式用于新生儿黄疸治疗中的效果。方法 130例黄疸新生儿作为研究对象,根据蓝光照射治疗方法的不同分为对照组与观察组,每组65例。全部新生儿均给予常规对症治疗,对照组新生儿给予持续性蓝光照射治疗,观察组新生儿给予间歇性蓝光照射治疗。对比分析两组新生儿的治疗效果。结果观察组患儿治疗总有效率为95.38%,高于对照组的90.77%,但差异无统计学意义(P>0.05)。观察组患儿的不良反应发生率为6.15%,低于对照组的20.00%,差异具有统计学意义(P<0.05)。治疗前两组患儿经皮胆红素水平比较差异无统计学意义(P>0.05);治疗72 h后两组经皮胆红素水平均较治疗前降低,差异具有统计学意义(P<0.05),但两组间比较差异无统计学意义(P>0.05)。观察组患儿胆红素降至正常的时间比对照组略短,但差异无统计学意义(P>0.05)。结论间歇性和持续性蓝光照射用于新生儿黄疸治疗中效果确切,有助于促进胆红素水平的下降,促进黄染的消退,促进患儿的早日康复,但是间歇性蓝光照射治疗的安全性高,有助于缩短住院时间,具有重要临床应用推广价值。

Objective To explore the effect of two blue light irradiation methods in the treatment of neonatal jaundice. Methods A total of 130 jaundice newborns as study subjects were divided by different blue light irradiation methods into control group and observation group, with 65 cases in each group. All newborns all received conventional treatment, and the control group received continuous blue light irradiation treatment. The observation group received intermittent blue light irradiation treatment. Treatment effect was compared and analyzed in two groups. Results The observation group had higher total treatment effective rate as 95.38% than 90.77% in the control group, but the difference had no statistical significance （P〉0.05）. The observation group had lower incidence of adverse reactions as 6.15% than 20.00% in the control group, and the difference had no statistical significance （P〈0.05）. Both groups had no statistically significant difference in transcutaneous bilirubin level before treatment （P〉0.05）. After 72 h of treatment, both groups had lower transcutaneous bilirubin level than before treatment, and the difference had statistical significance （P〈0.05）, hut both groups had no statistically significant difference （P〉0.05）. The observation group had shorter bilirubin drop to normal time than the control group, but the difference had statistical significance （P〉0.05）. Conclusion Intermittent and continuous hlue light shows affirmative effect for the treatment of neonatal jaundice, and they are helpful to promote hilirubin level decline, yellow dye fade, and early recovery of children. While intermittent blue light treatment is of high safety, and it also help to shorten hospital stay time. So it has great clinical application and promotion value.