2%酮康唑洗剂对炎热地区部队特发性瘙痒症患者疗效与生活质量的影响

Efficacy of 2% ketoconazole lotion in the treatment of idiopathic pruritus patients of hot area troops and its influence on the patients' life quality index

目的观察2%酮康唑洗剂对炎热地区部队特发性瘙痒症患者疗效及生活质量的影响。方法将确诊为特发性瘙痒症的165例患者随机分为3组,试验组69例,给予2%酮康唑洗剂联合咪唑斯汀治疗,对照组56例,给予咪唑斯汀单用治疗,安慰剂组40例,给予安慰剂联用咪唑斯汀治疗;疗程均为4周,于治疗前及治疗后第4、8周进行随访。瘙痒程度采用视觉模拟量表(VAS)评定,并根据症状积分下降指数进行整体疗效评估;利用皮肤病生活质量指数(DLQI)调查问卷评价患者生活质量改善情况。结果治疗前3组患者症状积分、DLQI积分差异无统计学意义;治疗4周结束时,试验组有效率为65.22%,对照组为62.50%,安慰剂组为65.00%;3组均比治疗前有显著改善(P<0.05);而组间差异无统计学意义(P>0.05);3组DLQI评分较治疗前均下降,但各组之间差异无统计学意义(P>0.05)。治疗后第8周,试验组有效率(50.72%)显著高于对照组(21.43%)和安慰剂组(20.00%),差异均有统计学意义(P<0.01);3组DLQI评分均较治疗结束时增高,但试验组DLQI评分低于对照组和安慰剂组,差异有统计学意义(P<0.05)。结论 2%酮康唑洗剂联合咪唑斯汀能有效改善慢性特发性瘙痒症患者的远期症状,同时能提高患者的生活质量。

Objective To observe the efficacy of 2% ketoconazole lotion in the treatment of idiopathic pruritus patients of hot area troops and its influence on the patients＇ life quality index. Methods A total of 165 cases that diagnosed as idiopathic pruritus were randomly divided into three groups： 69 cases in the experimental group treated with mizolastine combined with 2% ketoconazole lotion, 56 cases in the control group treated with mizolastine alone and 40 cases in the placebo-controlled group treated with mizolastine combined with placebo. The course of treatment lasted for 4 weeks. Follow up was carried out at four and eight weeks after the treatment finished. The degree of pruritus was assessed by visual analogue scale（VAS）, and the overall efficacy was assessed by symptom score index（SSl）. The improvement of patients＇ quality of life was evaluated by dermatology life quality index （DLQI） questionnaire. Results There was no significant difference in symptom score and DLQI score among the 3 groups before treatment. At the 4th week after the treatment, the efficiency of the experimental group was 65.22%, as 62.50% for the control group and 62.50% for the placebo-controlled group, and there was no statistical difference between the every two groups（P〉0.05）. At the same time point, the DLQI score of the 3 groups all decreased, similarly there was no significant difference between the every two groups（P〉0.05）. At the 8th week after the treatment, the efficacy of the experimental group was significantly higher than that of the other two groups（P〈0.01）; the DLQI score of the 3 groups were all higher than that of the end of treatment, but the DLQI score of the experimental group was lower than that of the other two groups, and the difference had statistical significance（P〈0.05）. Conclusion The treatment of 2% ketoconazole lotion combined with mizolastine not only can effectively improve the long-term symptoms of the patients with chronic idiopathic pruritus, but also improve the patients＇ quality of life.