突发性耳聋患者凝血状态研究

Study on coagulation state of sudden deafness patients

目的：探讨成年人突发性耳聋（简称突聋）患者诊治过程中的凝血状态。方法：选取未经治疗的成年突聋患者40例作为突聋组，选择性别、年龄相匹配的正常听力人群40例作为对照组，两组均进行血小板（PLT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）、血栓弹力图（TEG）检查，对两组结果进行比较。突聋组患者在经过1个疗程治疗后再次进行PLT、PT、APTT、FIB和TEG检查，对治疗前、后的结果进行比较。结果：突聋组患者PLT和FIB高于对照组，TEG检测中突聋组R值和K值低于对照组，Ma值则高于对照组，差异均具有统计学意义（P〈0．05）；突聋组患者在治疗后，PT、R值和K值升高，FIB、Angle角和Ma值降低，差异均具有统计学意义（P〈0．05或0．01）。结论：常规凝血检查联合血栓弹力图检测有利于突发性耳聋的诊断和疗效评估。

Objective： To evaluate the coagulation status in adult patients suffering from sudden sensorineural hearing loss （SSHL） . Methods： Forty adults suffering from SSHL were collected before treatment as SSHL group. Forty normal hearing individuals with matched sex and age were enrolled into the control group. Platelet count （PLT） , prothrombin time （PT） , activated partial thromboplastin time （APTT） , fibrinogen （FIB） and thrombelastogram （TEG） indexs were determined and compared between two groups; PLT, PT, APTT, FIB, and TEG of SSHL group patients were determined again after one period of treatment. The obtained results were compared with the results before treatment. Results： PLT and FIB of SSHL group were higher than that of control group. In TEG test, 1k and K values were lower than that of control group, while Ma value higher than that in control, with significant difference （P〈0.05） ; After treatment, PT, P,. and K of SSHL group all increased significantly, and FIB, Angle, and Ma all declined significantly （P〈0.05 or P〈0.01） . Conclusion： The evaluation of coagulation status combined with TEG test plays a simiificant role in the diamaosis and treatment of adult SSHL patients.