血栓通联合依达拉奉对老年急性脑梗死患者氧化低密度脂蛋白和MMPs水平的影响及临床疗效

Effects of Xueshuantong and Edaravone on Oxidized Low Density Lipoprotein and MMPs Levels of Elderly Patients with Acute Cerebral Infarction

目的:探讨血栓通联合依达拉奉对老年急性脑梗死患者氧化低密度脂蛋白及MMPs水平的影响及临床疗效。方法:收集我院收治的126例急性脑梗死患者,随机分为实验组和对照组,每组各63例。对照组患者给予血栓通注射液治疗;实验组患者在对照组基础上给予依达拉奉治疗。观察并比较两组患者治疗前后血清氧化低密度脂蛋白(Ox-LDL)、基质金属蛋白酶2(MMP-2)及基质金属蛋白酶9(MMP-9)水平的变化情况以及临床疗效。结果:与治疗前相比,治疗后两组患者Ox-LDL,MMP-2及MMP-9水平均下降,差异具有统计学意义(P<0.05);与对照组相比,实验组患者Ox-LDL,MMP-2及MMP-9水平较低,差异具有统计学意义(P<0.05);与对照组相比,实验组患者的临床疗效较高,差异具有统计学意义(P<0.05)。结论:血栓通联合依达拉奉能够降低老年急性脑梗死患者氧化低密度脂蛋白(Ox-LDL)、基质金属蛋白酶2(MMP-2)以及基质金属蛋白酶9(MMP-9)水平,临床疗效较好。

Objective： To investigate the effect of xueshuantong combined with edaravone on the levels of oxidized low density lipoprotein and MMPs of elderly patients with acute cerebral infarction and its clinical efficacy. Methods： 126 cases with acute cerebral infarction who were treated in our hospital were selected and randomly divided into the experimental group and the control group, with 63 cases in each group. The patients in the control group was treated with xueshuantong injection, and the patients in the experimental group were treated with edaravone on the basis of the control group. Then the levels of oxidized low density lipoprotein （Ox-LDL）, ma- trix metalloproteinase 2 （MMP-2） and matrix metalloproteinase 9 （MMP-9） of patients in the two groups and the clinical efficacy were observed and compared before and after the treatment. Results： Compared with before treatment, the levels of Ox-LDL, MMP-2 and MMP-9 in the two groups decreased after treatment, and the differences were statistically significant （P〈0.05）; Compared with the control group, the levels of Ox-LDL, MMP-2 and MMP-9 in the experimental group were lower and the differences were statistically significant （P〈0.05）; Compared with the control group, the clinical effective rate in the experimental group was higher, and the difference was statis- tically significant （P〈0.05）. Conclusion： Xueshuantong and edaravone can reduce the levels of oxidation low density lipoprotein （Ox-LDL）, matrix metalloproteinase 2 （MMP-2） and matrix metalloproteinase 9 （MMP-9） of elderly patients with acute cerebral infarc- tion with better clinical curative effect.