乙肝患者血清标志物与肝纤维化血清学指标的相关性分析

Correlative Analysis of the Hepatitis B Serological Biomarkers with Serum Liver Fibrosis Biomarkers

目的:探讨乙肝患者血清标志物与肝纤维化血清学指标的相关性。方法:收集我院收治的136例乙型病毒肝炎患者,根据轻中重程度分为轻度组、中度组以及重度组,每组42例。观察并比较所有患者乙肝血清标志物、HBV-DNA水平、透明质酸(HA),血清Ⅲ型前胶原肽(PCⅢ),Ⅳ型胶原(CIV)水平以及层粘连蛋白(LN)水平。结果:三组患者的HBV-DNA水平依次升高,与轻度组相比,中度组、重度组患者HBV-DNA水平较高,与中度组患者相比,重度组患者HBV-DNA水平较高,差异具有统计学意义(P<0.05)。与轻度组相比,中度组、重度组患者HA、PCⅢ、CIV、LN水平较高,与中度组患者相比,重度组患者HA、PCⅢ水平较高,差异具有统计学意义(P<0.05);HBV-DNA水平与HA、PCⅢ、CIV、LN水平均呈显著正相关。结论:乙肝患者的血清学检测指标与血清肝纤维化测定有助于对乙肝的纤维化过程的进展情况进行评估。

Objective： To investigate the significance of serum liver fibrosis in patients with hepatitis B in clinical research. Methods： 136 cases of hepatitis B patients admitted to our hospital were divided into 3 groups according to the degree of mild, moderate, severe, mild group, moderate group and severe group, 42 cases in each group. All patients were observed and compared with HBV markers, HBV-DNA levels, hyaluronic acid （HA）, serum type III collagen peptide （PCIII）, type IV collagen （C1V） and laminin （LN） levels. Results： HBV-DNA levels in three groups of patients was gradually increased, compared with that of the mild group, moderate group and severe group and the HBV-DNA level are higher, and compared with moderate group patients, severe group patients HBV-DNA level is higher, the difference is statistically significant （P〈0.05）. Compared with the mild group, moderate group and severe group patients HA, PCIII, ely and LN levels are higher, and compared with moderate group patients, patients in the severe group ha, PCIII level is higher, the differ- ence is statistically significant （P〈0.05）; HBV-DNA level was positively correlated with the HA, PCIII, CIV and LN levels. Conclusions： The serological detection indexes of hepatitis B patients and serum liver fibrosis were determined, which could be used to evaluate the progress of hepatitis B fibrosis process.