光照功率密度及照射方式对光动力疗法影响的研究进展

Advances of Research on Impacts of Light Parameters on Photodynamic Therapy

光照是光动力治疗中的重要因素。通过调节光照参数,可以使在同样用药方式和剂量等条件下的光动力治疗效果更好。近年来,该领域的众多研究者对光照参数对光动力疗法的影响以及作用的机制进行了深入的研究。这些研究集中在功率密度对光动力疗法的效果以及影响机制上。低功率密度的策略有助于产生充分的单线态氧,并可能对细胞死亡机制与免疫效应产生影响。同时,分段式光照等光照模式的采用也有可能弥补光动力治疗中的一些不足。但是由于目前尚缺乏系统的理论研究与技术手段,这些光照参数通过何种细胞生物学机制而产生作用有待进一步的研究。

Light is a critical element in photodyuamic therapy （PDT）. The drug-limiting outcome of the therapy can be opti- mized via moderating light parameters. The impact of light parameters on PDT and the mechanism had been studied intensively in the past decade. In this review, the impactand mechanism is discussed. It is believed that low fluence rate facilitates the production of suf- ficient singlet oxygen to modify cell death pathway and immune response. Meanwhile, it is suggested that new models like fraction light is helpful to PDT. However, due to lack of systemic study and method, the functional mechanism of light parameters should be studied further to facilitate clinical practice.