摘要
The restenosis after coronary artery bypass graft(CABG) is attributed to the formation of intimal hyperplasia(IH) at the anastomosis,which is closely related to hemodynamic depend on the geometric model. In order to give a reasonable assessment of the surgery effect and judge the long-term patency rate,the hemodynamic of CABG surgery program is compared with that of surgery design of the junction angle changed.Based on in-vivo CT coronary angiography datasets,the individual geometric model of CABG reconstructed instead of idealized geometric models are applied to simulate the real physiological blood flow utilizing pulsatile flow boundary waveforms in the present study. The simulation results show that the maximum wall shear rate(WSS) value is at the bottom of anastomosis. Moreover,the stagnation zone growing gradually with the greater angle downstream the anastomosis is prone to form the IH,which is consistent with clinical observation. It is proved that the surgery being better suited to maintain graft patency is successful.
The restenosis after coronary artery bypass graft（CABG） is attributed to the formation of intimal hyperplasia（IH） at the anastomosis,which is closely related to hemodynamic depend on the geometric model. In order to give a reasonable assessment of the surgery effect and judge the long-term patency rate,the hemodynamic of CABG surgery program is compared with that of surgery design of the junction angle changed.Based on in-vivo CT coronary angiography datasets,the individual geometric model of CABG reconstructed instead of idealized geometric models are applied to simulate the real physiological blood flow utilizing pulsatile flow boundary waveforms in the present study. The simulation results show that the maximum wall shear rate（WSS） value is at the bottom of anastomosis. Moreover,the stagnation zone growing gradually with the greater angle downstream the anastomosis is prone to form the IH,which is consistent with clinical observation. It is proved that the surgery being better suited to maintain graft patency is successful.
