快眼动睡眠调控机制及快眼动睡眠期行为障碍的神经通路相关研究

The Putative Neuronal Networks Responsible for Rapid Eye-movement Sleep and Rapid Eye Movement Behavior Disorder

快眼动(REM)睡眠行为障碍(RBD)是一种以REM睡眠期骨骼肌弛缓能力障碍为特征的异态睡眠。患病个体因此在REM睡眠期出现不同严重程度的与梦境吻合的异常行为。至今与RBD相关的神经核团及通路尚未完全阐明,存在不同假说。文中从REM睡眠神经调控机制入手,结合猫和大鼠RBD模型发现,回顾近年来RBD相关神经通路研究的进展,并与人类RBD病例对照,综合阐述RBD产生的相关神经通路,为RBD发病机制的研究进一步提供线索。

Rapid eye-movement （REM） sleep behavior disorder is a parasomnia characterized by loss of muscle atonia during REM sleep. Neurons and neuronal circuits responsible for REM sleep behavior disorder （RBD） have not been confirmed. The control mechanism relating to REM sleep was discussed, and the known and presumed neural networks involved in REM sleep and RBD pathophysiology based on animal models were reviewed. Human RBD cases were used as reference, the putative neuronal circuits causing RBD were discussed, in order to promote better clarification for the clinical and pathophysiological causes of RBD.