白细胞膜微粒在动脉粥样硬化发生发展的作用

The Role of Leukocyte-derived Microparticles in the Development of Atheroselerosis

白细胞膜微粒是白细胞在活化、损伤或凋亡时,从其表面释放的富含脂质的膜囊泡,其在内皮细胞损伤、血管功能障碍、氧化应激、炎症反应及细胞之间的信号传导等方面发挥重要作用。近来研究发现,在动脉粥样硬化基础上发生的心脑血管疾病、血栓栓塞性疾病、代谢性疾病和恶性高血压病等疾病中白细胞膜微粒明显增高。文中就白细胞膜微粒对动脉粥样硬化发生发展的作用进行概述。

Leukocyte-derived microparticles （LMPs） are lipid submicron vesicles shed from plasma membranes of vascular leukocyte cells in response to leukocyte activation, injury or apoptosis. LMPs play an important role in endothelial cell injury, vessel dysfunction, oxidative stress, inflammatory reaction and cell signal transduction and so on. The level of circulating and plaque LMPs increased in a series of diseases based on atherosclerosis, such as cardio-cerebrovascular diseases, thromboembolie disease, metabolic disease and malignant hypertension and so on. The role of LMPs in the development of atheroselerosis was reviewed.