补肾活血法治疗退行性骨关节炎临床观察

Clinical Observation of Nourishing Kidney and Activating Blood Therapy for Degenerative Osteoarthritis

目的:观察补肾活血法治疗退行性骨关节炎的临床疗效。方法:将48例退行性骨关节炎患者,按照随机数字表法分为2组各24例。对照组给予洛索洛芬钠片口服,观察组给予补肾活血方口服。比较2组治疗总有效率,治疗前后血清血管内皮细胞生长因子(VEGF)和促血管生成素-1(Ang-1)水平。结果:总有效率观察组为91.7%,对照组为62.5%,2组比较,差异有统计学意义(χ~2=5.779,P=0.016)。治疗前,2组血清VEGF、Ang-1水平比较,差异均无统计学意义(P>0.05)。与治疗前比较,治疗后2组上述指标均降低(P<0.01),治疗后观察组血清VEGF、Ang-1水平均低于对照组,差异均有统计学意义(P<0.01)。2组不良反应发生率比较,差异无统计学意义(χ~2=0.762,P=0.333)。结论:补肾活血法治疗退行性骨关节炎,可有效减轻患者的疼痛,改善其膝关节功能,疗效确切,其治疗机制可能与降低血清VEGF、Ang-1水平有关。

Objective：To observe the clinical effect of nourishing kidney and activating blood therapy for degenerative osteoarthritis.Methods：Selected 48 patients with degenerative osteoarthritis,and divided them into two groups with 24 cases in each,according to the random number table method.The control group was given oral loxoprofen sodium tablets,and the observation group was given oral nourishing kidney and activating blood therapy.Compared the total effective rate of the two groups,and levels of serum vascular endothelial growth factor（VEGF）,angiopoietin-1（Ang-1） of the two groups.Results：The total effective rate was 91.7%in the observation group,and was 62.5%in the control group,the difference being significant（χ2=5.779,P=0.016）.Compared levels of serum VEGF,Ang-1 of the two groups before treatment,there was no significant difference（P〉0.05）.Compared with before treatment,the above indexes of the two groups were decreased（P〈0.01）,and levels of serum VEGF,Ang-1 of the observation group were lower than those of the control group（P〈 0.01）.No significant difference was found in the incidence of adverse reaction of the two groups（χ2=0.762,P=0.333）.Conclusion：Nourishing kidney and activating blood therapy can relieve pain,improve knee joint function,and has good clinical efficacy in treating degenerative osteoarthritis,whose mechanism maybe related to the decrease of levels of serum VEGF and Ang-1.