三黄健齿汤联合牙周局部治疗对慢性牙周炎临床疗效及炎症因子的影响

Influence of Clinical Effect and Inflammatory Factors of Sanhuang Decoction Combined with Tooth Periodontal Local in Treatment on Chronic Periodontitis

目的:研究三黄健齿汤联合牙周局部治疗慢性牙周炎的临床疗效,并观察其对炎症因子的影响,为临床诊疗提供依据。方法:选取2015年10月到2016年3月我院收治慢性牙周炎患者130例,按照随机数字表法将患者分为治疗组和对照组,每组65例,对照组给予洁治和龈下刮治、根面平整等,治疗组在对照组的基础上给予三黄健齿汤治疗,比较治疗前和治疗后牙周探诊深度(PD)、牙龈出血指数(BI)、牙龈沟液白介素-1β(IL-1β)、白介素-6(IL-6)水平变化,并比较中医证候评分。结果:治疗后两组PD和BI均显著降低,差异有统计学意义(P<0.05),但两组间比较差异无统计学意义(P>0.05);治疗后两组IL-1β和IL-6均显著降低,且治疗组低于对照组,差异有统计学意义(P<0.05);治疗后两组中医主证候群和次证候评分均显著降低(P<0.05),两组主证候群评分比较差异无统计学意义(P>0.05),治疗组次证候评分显著低于对照组(P<0.05)。结论:三黄健齿汤联合牙周局部治疗对慢性牙周炎具有较好疗效,能有效降低炎症因子,改善次证候评分。

Objective： To study the clinical effect of Sanhuang Decoction Combined with tooth periodontal local in treatment on chronic periodontitis, and to observe its influence on inflammatory factors, to provide the basis for clinical diagnosis and treatment. Methotis： 130 cases of patients with chronic periodontitis from May 2014 to May 2016 in our hospital were selected,there were divided into treatment group and control group according to the random number table method,65 cases in each group,the control group was given scaling and subgingival scaling and root planing etc,the treatment group was given Sanhuang Decoction on the basis of the control group, periodontal probing depth （PD）, gingival bleeding index （BI）, gingival crevicular fluid intedeukin -1 beta （IL-1 beta） and interleukin -6 （IL-6） level change before treatment and after treatment were compared, and compared TCM syndrome score. Results： PD and BI were significantly decreased in the two groups after treatment, the difference was statistically significant （P〈0.05）, but there was no significant difference between the two groups （P〉0.05）; IL-1β and IL-6 were significantly decreased in the two groups after treatment, and the treatment group was lower than the control group, the difference was statistically significant （P〈0.05）; Syndrome and syndrome of traditional Chinese Medicine were significantly decreased in the two groups after treatment（P〈0.05）, there was no significant difference of primary syndrome score in the two groups （P〉0.05）, the syndrome score in the treatment group was significantly lower than the control group （P〈0.05）. Conclusion： Sanhuang Decoction Combined with tooth periodontal local treatment has good curative effect on chronic periodontitis, can effectively reduce the inflammatory factor, improve the secondary syndrome score.