补骨脂ADME及其相关毒性的研究进展

A Progress on ADME and the Toxicity of Fructus Psoralea

补骨脂是临床常用的补益类中药,其化学成分复杂,主要包括香豆素、黄酮及单萜酚等化合物类型。补骨脂提取物及其单体成分具有广泛的药理作用。随着临床不良反应报道日益增加,补骨脂的肝、肾毒性及皮肤过敏等毒副作用逐渐引起重视。本文归纳总结补骨脂提取物及其主要成分在机体内的吸收(Absorption)、分布(Distribution)、代谢(Metabolism)及排泄(Excretion)过程(ADME),并对其临床不良反应及相关毒性研究进行综述,为补骨脂的科学安全应用提供相关依据和思路。

Fruetus psoralea is a tonic traditional Chinese herb commonly used in clinic. The chemical constituents of Fructus psoralea are complicated, mainly containing coumarins, flavonoids and monoterpene phenols with various pharmacological effects. Since the increasing number of reports on the toxicity of Fructus psoralea in clinic, the side effects including toxicity on the liver and kidney, as well as skin allergies have gradually attracted attention. The toxicity of Fructus psoralea is produced from ADME （absorption, distribution, metabolism and excretion） in vivo. In this paper, we collected and clarified the studies of ADME of Fructus psoralea in vivo, and summarized recent adverse clinical events and research over its toxicity. We propose to make a thorough study on the toxic material basis of Fructus psoralea and the toxicological mechanism of its extraction, fractions and compounds. The review provided a possible reference and the direction of research for the safe clinical use of Fructus psoralea.