P53和Ki-67在喉鳞状细胞癌中的表达及与短期预后的关系

Expression of P53 and Ki-67 in laryngeal squamous cell carcinoma and the short-term prognosis

目的:探讨P53和Ki-67在喉鳞状细胞癌(laryngeal squamous cell carcinoma,LSCC)中的表达情况及临床病理参数和短期预后相关分析。方法:选择手术切除LSCC标本35例,肿瘤分期均为T3~4N0M0。采用SP法染色进行P53和Ki-67免疫组织化学标记,结合临床病理参数和2年随访结果及无病生存情况进行统计学分析。结果:LSCC标本P53阳性率为60.00%;2年复发率P53阳性患者76.19%高于P53阴性28.59%,差异具有统计学意义(P=0.013)。年龄大小、是否抽烟、增殖指数高低及肿瘤不同分级方面,患者2年内复发率差异均无统计学意义。T3~4N0M0分期患者的短期预后与P53表达高低相关。结论:P53的过表达对晚期LSCC短期预后评估具有一定的临床意义,可考虑作为晚期LSCC分层治疗指标。

Objective：To study the expression of P53 and Ki-67 protein in laryngeal squamous cell carcinoma（LSCC） and the relation with parameters of clinicopathology and short-term prognosis.Methods：The expression of P53 an Ki-67 was examined by SP immunohistochemistry in 35 cases of LSCC,with tumor stage were T3–4N0M0.The results were subjected to statistics analysis,combined with the clinical pathologic data and short-term prognosis.Results：In 35 cases LSCC,2-year recurrence of the P53 positive expression was 60.0%;the recurrence rate of P53 positive（76.19%） was higher than that of P53 negative（28.59%）,The difference was statistically significant（P=0.013）.There was no significant difference in the recurrence rate between the two groups in age,smoking,value added index,and tumor grade.The short-term prognosis of patients with T3–4N0M0 stage was correlated with the expression of P53.Conclusion：Overexpression of P53 may play a role in the judgment of prognosis of later period LSCC and can be used as index of later period LSCC stratification treatment.The number of cases studied is less,and more data are needed to verify.