硫化氢与microRNA的调节作用及其对心血管疾病的影响

Effects of the mutual regulations between hydrogen sulfide and microRNAs on cardiovascular diseases

心血管疾病(cardiovascular disease,CVD)为世界头号死因。硫化氢(hydrogen sulfide,H_2S)作为一种气体信号分子,通过促血管生成、血管舒张、抗血管内皮细胞衰老等机制,在CVD发生发展过程中发挥着重要作用。近年来的研究表明H_2S可通过调节某些microRNA(miRNA)来改善心脏功能。miRNA是真核细胞中发现的一类高度保守的非编码小RNA分子,通过抑制蛋白质翻译和加速mRNA的降解从而调节基因表达。miRNA有望成为CVD的干预靶点。某些miRNA也可调节H_2S的生物合成,这两者之间的调节作用开辟了CVD发生发展机制与干预研究的新途径。

Cardiovascular disease（CVD） is the leading cause of death worldwide.Hydrogen sulfide（H2S）,as a gaseous signaling molecule,plays an important role in the development of CVD by promoting angiogenesis,stimulating vasodilation and preventing vascular endothelial cell senescence.Recent studies have shown that H2S can improve cardiac functions by regulating expressions of microRNAs and their bioactivities.miRNAs are a class of highly conserved,noncoding small RNA molecules found in eukaryotic cells,which regulate gene expression by inhibiting protein translation and accelerating mRNA degradation,and are expected to be intervention targets for CVD.Some miRNAs can also modulate the biosynthesis of H2S,and the mutual regulations between H2S and miRNAs open up a new pathway for exploration of CVD development and intervention.