原发性卵巢Burkitt淋巴瘤病理分析1例并文献复习

Pathological analysis of primary ovarian Burkitt lymphoma:a case report and literature review

目的:为了更好地认识原发性卵巢Burkitt淋巴瘤(Burkitt's lymphoma,BL)的临床表现、病理特征及其预后。方法:收集1例原发性卵巢BL的病例及其参考文献资料,观察其临床表现、临床病理学特征、免疫组织化学染色及1年的预后。结果:原发性卵巢BL临床表现主要为腹部或盆腔肿块,镜下可见肿瘤细胞弥漫增生,主要由淋巴样细胞组成,细胞中等大小,弥漫生长,细胞核圆形或卵圆形,染色质粗块状,核仁中等大小,嗜碱性,其中散在巨噬细胞,成"星空现象",免疫组织化学结果显示:CD79a(+),CD20(+),CD3(–),CD10(+),BCL-6(+),BCL2(–)和Ki-67(>90%)。结论:诊断原发性卵巢BL需结合组织学及免疫组织化学结果,并对其鉴别诊断加以区分。

Objective：To have a better understanding of the clinical manifestations,pathological features and prognosis of primary ovarian Burkitt lymphoma（BL）.Methods：A primary ovarian BL case and pertinent literature were collected,the clinical manifestations,pathological features,immunohistochemical staining and 1 year prognosis were observed.Results：The main clinical manifestations of primary ovarian BL were abdominal or pelvic masses,microscopically tumor cells diffuse hyperplasia,mainly composed of lymphoid cells,medium size cells,diffuse growth,round or oval nuclei,coarse chromatin,medium size nucleolus,and basophilic;the macrophages were scattered and distributed into ＂star phenomenon＂ under microscope.Immunohistochemical results were：CD79a（＋）,CD20（＋）,CD3（–）,CD10（＋）,BCL-6（＋）,BCL2（–）,and Ki-67（〉90%）.Conclusion：The diagnosis of primary BL should be combined with histological and immunohistochemical findings,and the differential diagnosis should be distinguished.