干扰素联合丙种球蛋白治疗儿童传染性单核细胞增多症的疗效

Interferon combination gamma globulin treatment the curative effect of infectious mononucleosis in children

目的探讨干扰素联合丙种球蛋白治疗传染性单核细胞增多症(IM)患儿的临床疗效。方法选取2014年3月至2016年3月于深圳市罗湖区人民医院儿科治疗的80例IM患儿作为研究对象,按随机数字表法分为观察组与对照组,各40例。对照组患儿采用干扰素进行治疗,观察组采用干扰素联合丙种球蛋白治疗方案,比较两组患儿治疗效果、症状改善时间、实验室指标改善情况及T淋巴细胞亚群变化。结果观察组患儿治疗有效率为92.5%,显著高于对照组的77.5%,差异有统计学意义(P<0.05);观察组患儿退热时间、咽颊炎消退时间、淋巴结缩小时间、肝脾缩小时间均明显短于对照组,差异均有统计学意义(均P<0.05);治疗后,观察组患儿白细胞总数、谷氨酸转氨酶(ALT)及肌酸激酶同工酶(CK-MB)均明显低于对照组,差异均有统计学意义(均P<0.05);治疗后观察组患者CD3^+CD4^+、CD3^+CD4^+/CD3^+CD8^+均显著高于对照组,CD3^+CD8^+明显低于对照组,差异均有统计学意义(均P<0.05)。结论干扰素联合丙种球蛋白治疗儿童IM疗效显著,症状改善快,可增强机体细胞免疫功能,具有积极临床意义。

Objective To study the interferon combination gamma globulin treatment the curative effect of infectious mononucleosis in children.Methods 80 children with IM treated in Shenzhen people＇s Hospital of Luohu District from March 2014 to March 2016 were randomly divided into observation group and control group,each with a total of 40 cases.The control group were treated with interferon treatment,observation group were treated with interferon combined with gamma globulin treatment,compared two groups of curative effect,symptom improvement time, improving laboratory index and the changes of T lymphocyte subsets.Results The effective rate of the observation group was 92.5%,significantly higher than 77.5% in the control group,the difference was statistically significant（P〈0.05）; the observation group with fever, pharyngitis subsided time, lymph nodes,liver and spleen reduced time time were significantly shorter than the control group,the differences were statistically significant（P〈0.05）;after treatment,the observation group with the number of white blood cells,glutamate transaminase（ALT） and creatine kinase isoenzyme （CK-MB） were significantly lower than the control group,the differences were statistically significant（P〈0.05）;after treatment,the observation group were CD3^＋CD4^＋,CD3^＋CD4^＋/CD3^＋CD8^＋ were significantly higher than control group, CD3^＋CD8^＋was significantly lower than the control group,the differences were statistically significant the significance （P〈0.05）.Conclusion Interferon combined with gamma globulin in treatment of children IM significant effect,improvement of symptoms, can enhance immune function,has positive clinical significance.