脑梗死患者病灶部位与早期抑郁症状的相关性分析

Relationship between the lesion location and early depressive symptoms in cerebral infarction patients

目的探讨急性脑梗死患者病变部位与早期抑郁症状发生的关联。方法研究对象是85例急性脑梗死患者。入院当天,使用MRI确定患者病变部位。住院治疗7天,采用NIHSS方法评估脑卒中的严重程度。住院治疗10天,采用汉密顿抑郁量表(HADM)和功能独立性评估抑郁症状。结果 14例患者(16.9%)被诊断为抑郁。根据多元逻辑回归分析,额叶和颞叶的病灶,是患者在急性期出现抑郁症状的独立危险因素。结论急性脑梗死患者,特别是额叶和颞叶,应仔细评估并治疗早期抑郁症状。

Objective To examine the relationship between the lesion location and the presence of early depressive symptoms after acute cerebral infarction.Methods Our study included 85 patients who suffered from acute cerebral infarction.On the day of admission,the lesion location was determined using MRI.Stroke severity was measured on the seventh day of hospitalization with at the National Institutes of Health Stroke Scale（NIHSS）.On the tenth day of hospitalization,depressive symptoms were measured and functional assessments were performed with the Hamilton depression rating scale（HADM） and functional independence measure.Results A total of 14 subjects（16.9 %）were diagnosed with depression.According to the multiple logistic regression analysis,the infarcts located at frontal and temporal lobes were found to be a significant independent risk factor of depressive symptoms in the acute stage of patients.Conclusion Patients suffering from acute cerebral infarction,particularly in the frontal and temporal lobes,should be carefully assessed to detect and treat early depressive symptoms.