摘要
目的探讨胆道闭锁(biliary atresia,BA)患儿血清血红素氧化酶-1(hemeoxygenase-1,HO-1)表达水平及其临床意义。方法连续收集2015年10月1日-2015年12月31日间接受亲属活体供肝移植的BA患儿20例,于术前1周采集受者外周静脉血,采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测血中HO-1的表达量。同时记录相关临床指标。选取5例健康同龄儿童作为对照组。结果 BA患儿血清HO-1测定值高于对照组(P<0.001)。直接胆红素与HO-1呈正相关(相关系数R=0.576,P=0.008)。结论 BA患儿血清HO-1值升高与胆道梗阻程度相关。
Objective To investigate the level of serum hemeoxygenase-1（HO-1） in biliary atresia（BA） and its clinical significance. Methods We selected 20 cases children suffered from BA which treated with pediatric living donor liver transplantation from October 1, 2015 to December 31, 2015, vein blood was collected at one week before operation, and measured the HO-1 expression by enzyme-linked immunosorbent assay（ELISA）. Other clinical indicators were recorded at the same time. Five normal children were selected as control group. Results The expression of HO-1 in patients were increased compared to the healthy children groups before operation（P〈0.001）. Direct bilirubin was positively correlated with HO-1（R = 0.576,P =0.008）. Conclusion The expression of HO-1 in children with BA was related to the degree of biliary obstruction.
出处
《实用器官移植电子杂志》
2017年第1期15-17,共3页
Practical Journal of Organ Transplantation(Electronic Version)
基金
天津市卫生行业重点攻关项目(13KG103)
国家临床重点专科建设项目(2013544)
