美托洛尔与卡维地洛治疗慢性心力衰竭的疗效比较

Comparison of curative effect of carvedilol and metoprolol in the treatment of chronic heart failure

目的对比研究美托洛尔与卡维地洛治疗慢性心力衰竭(CHF)的疗效。方法 66例CHF患者随机分为A、B两组,每组33例,分别采用美托洛尔、卡维地洛治疗,总疗程均为12周。对比两组的疗效。结果 B组总有效率为97.0%,显著高于A组的78.8%(P<0.05);治疗后B组的左心室射血分数(LVEF)显著高于治疗前及A组,左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、血清IL-6及TNF-α水平显著低于治疗前及A组,差异均有统计学意义(P<0.01)。结论美托洛尔与卡维地洛治疗CHF均可获得良好疗效,且卡维地洛的疗效更为显著,能够更好控制炎症反应与心功能,值得推广应用。

Objective To compare the efficacy of metoprolol and carvedilol in treatment of patients with chronic heart failure （CHF）. Methods receiving treatment with 66 patients with CHF were randomly divided into Group A and Group B, 33 cases in each group, metoprolol and treatment with carvedilol, respectively. The total treatment course was 12 weeks. The efficacy of the two groups was compared. Results The total effective rate in Group B was 97.0%, significantly higher than that in Group A （78.8%） （P〈0.05）; After treatment, LVEF in Group B was significantly higher than that before treatment and that of Group A, and the LVESD, LVEDD, serum IL-6 and TNF -α were significantly lciwer than that before treatment and Group A, and the difference was statistically significant （P〈0.01）. Conclusion Metoprolol and carvedilol can both achieve good efficacy in the treatment of CHF, but carvedilol achieves a more significant effect and can better control the inflammation and heart function, which is worth clinical promotion.