他汀类药物相关性肌痛与维生素D关系的研究

A study on the relationship between statin induced myalgia and vitamin D

目的观察他汀类药物治疗患者的维生素D水平与他汀相关性肌痛(statin induced myalgia,SIM)的关系,并寻找预测发生SIM的维生素D临界值。方法入选1 851例心血管病患者,随访3 a,测定其维生素D水平,并记录SIM的发生情况。结果完成随访的1 479例中,有311例接受他汀类药物治疗,其中75例发生SIM,SIM发生率为24.1%。维生素D水平越低,其SIM发生率越高。当维生素D水平为≤15μg/L时,其对SIM预测的敏感性、特异性、阳性预测值及阴性预测值都较高。结论他汀类药物应用患者中,低维生素D水平较易发生SIM。当维生素D水平≤15μg/L时,对SIM的预测价值较高。

Objective To observe the relationship between the level of vitamin D in the patients cured with statins and statin induced myalgia （SIM）, and to seek the critical value of vitamin D to predict the incidence of SIM. Methods 1 851 patients with cardiovascular diseases received follow-up for three consecutive years, and their level of vitamin D was measured and the incidence of SIM was recorded. Results Of 1 479 cases with follow-up completed, 311 cases received the treatment with statins, of which 75 cases （24.1%） had SIM, The lower the level of vitamin D, the higher the incidence of SIM is. When the level of vitamin D was ≤ 15 μg/L, its sensitivity, specificity and positive predictive value as well as negative predictive value in SIM prediction was relatively high. Conclusion Among the patients receiving treatment with statins, those with a low level of vitamin D level may be easy to have SIM. When the level of vitamin D is ≤ 15 μg/L, it has a higher value in predicting SIM.