麻痹性痴呆46例临床分析

Analysis of clinical features of general paresis of the insane: 46 cases

目的分析麻痹性痴呆的临床特征与治疗。方法回顾性分析我院收治的46例麻痹性痴呆患者的临床表现、实验室检查、影像学检查、心理测评及治疗方案等特点。结果麻痹性痴呆患者表现不同程度的MRI特征性改变,血液和脑脊液RPR和TPPA均阳性,大剂量青霉素治疗有效。结论麻痹性痴呆临床表现复杂多样化,神经系统各个部位都可受累,极易误诊,大剂量青霉素治疗有效。

Objective To study the clinical features of general paresis of the insane as well as the treatment. Methods 46 cases with general paresis of the insane admitted to our hospital were retrospective analyzed in terms of clinical manifestation, laboratory examination, imaging examination, psychological assessment and treatment regimen. Results The patients had MIKI characteristic change at different levels. The RPR and TPPA in blood and cerebrospinal fluid were positive. The treatment with high-dose penicillin was effective. Conclusion clinical manifestations of general paresis of the insane are complex and diverse, all parts of the nervous system may be involved, it is easy to be misdiagnosed, and the treatment with high-dose penicillin was effective.