放射性示踪技术在兽药代谢及残留消除研究中的应用

The Application of Radioactive Tracer Technique in Veterinary Drug Metabolism and Residue Depletion Research

研究兽药的代谢和残留消除对于指导临床安全用药,保证动物和人的健康具有重要意义。放射性示踪技术在兽药的代谢和残留消除中药物及代谢物定性、定量分析具有准确、可信度高等特点,因此得到广泛应用。本文对近年来放射性示踪技术在兽药代谢、残留消除中的应用进行了综述,概括了放射性示踪技术在研究兽药药动学、代谢以及物料平衡规律的优势,总结了放射性示踪技术在兽药残留靶组织及标示残留物确定等方面的广泛应用及重要意义,旨在为我国未来放射性示踪技术在兽药安全性评估等方面的应用提供理论支持。

Veterinary drug metabolism and residue depletion research is of great significance in guiding the clinical safe medication,thus ensuring domestic animal and human health. Radioactive tracer technique is highly reliable and accurate for qualitative and quantitative analysis of veterinary drug,especially in veterinary drug metabolism and residue depletion,so it has been widely used. This review discussed veterinary drug metabolism and residue depletion research based on radioactive tracer technique,summarized the advantage of the radioactive tracer technology in the study of veterinary drug pharmacokinetics,metabolism,material balance,and also summarized the widely application and greatly significance of the radioactive tracer technology in determining the residue target tissue and marker residue,and aimed at providing theoretical support for the application of the radioactive tracer technology in veterinary medicine safety assessment.