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促性腺激素联合来曲唑治疗对多囊卵巢综合征不孕症患者排卵情况及妊娠率的影响 被引量:41

Effect of human menopausal gonadotrophin combined with letrozole on ovulation and pregnancy rate of infertile patients caused by polycystic ovary syndrome
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摘要 目的探讨人绝经期尿促性腺激素(HMG)联合来曲唑治疗对多囊卵巢综合征(PCOS)不孕症患者排卵情况及妊娠率的影响。方法选取2015年3月-2016年3月该院收治的PCOS不孕症患者134例,依治疗方法设对照组与研究组,各67例。对照组予HMG治疗,研究组予HMG联合来曲唑治疗,观察两组排卵情况、妊娠率及生殖激素水平。结果研究组睾酮(T)、黄体生成素(LH)、促卵泡素(FSH)、雌二醇(E_2)水平低于对照组,差异有统计学意义(P<0.05);研究组排卵率与妊娠率86.58%、38.81%高于对照组的58.21%、17.91%,差异有统计学意义(P<0.05)。结论 HMG联合来曲唑治疗PCOS不孕症可改善生殖激素水平及排卵情况,提高妊娠率。 Objective To explore the effect of human menopausal gonadotrophin( HMG) combined with letrozole on ovulation and pregnancy rate of infertile patients caused by polycystic ovary syndrome( PCOS). Methods A total of 134 infertile patients caused by PCOS treated in the hospital from March 2015 to March 2016 were selected and divided into control group and study group,67 patients in each group. The patients in control group were treated by HMG,while the patients in study group were treated by HMG combined with letrozole.The ovulation rates,pregnancy rates,and reproductive hormones levels in the two groups were observed. Results The levels of testosterone( T),luteinizing hormone( LH),follicle-stimulating hormone( FSH),and estradiol( E2) in study group were statistically significantly lower than those in control group( P〈0. 05). The ovulation rate and pregnancy rate in study group were 86. 58% and 38. 81%,respectively,which were statistically significantly higher than those in control group( 58. 21%,17. 91%)( P〈0. 05). Conclusion HMG combined with letrozole can improve reproductive hormones levels,ovulation rate,and pregnancy rate in treatment of infertile patients caused by PCOS.
作者 刘静
出处 《中国妇幼保健》 CAS 2017年第7期1540-1541,共2页 Maternal and Child Health Care of China
关键词 促性腺激素 来曲唑 PCOS不孕症 妊娠率 排卵情况 Human menopausal gonadotrophin Letrozole Fertility caused by polycystic ovary syndrome Pregnancy rate Ovulation
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