广东河源地区患儿呼吸道感染病原学研究

Etiological study of respiratory tract infections in children from Heyuan of Guangdong

目的探讨河源地区9项呼吸道病原体Ig M抗体在呼吸道感染儿童中的流行病学特点,为临床有效防治提供依据。方法收集诊断为呼吸道感染的922例患儿的血清,应用间接免疫荧光法检测嗜肺军团菌(LP1)、肺炎支原体(MP)、Q热立克次体(COX)、肺炎衣原体(CP)、腺病毒(ADV)、呼吸道合胞病毒(RSV)、甲型流感病毒(IFA)、乙型流感病毒(IFB)、副流感病毒1型、2型和3型(PIVS)Ig M抗体。结果 922例患儿中,9项呼吸道病原体Ig M抗体阳性率为29.39%(271/922),阳性率较高的为PIVS(14.21%)和MP(14.10%),COX未检出阳性。不同性别间比较,差异无统计学意义(χ~2=0.338,P>0.05)。按年龄分组比较显示,除1岁组与各组间比较差异有统计学意义外,其他各组间比较差异均无统计学意义。以单一感染为主,混合感染率为7.16%,以肺炎支原体并发副流感病毒感染最多。结论呼吸道9项病原体Ig M抗体联检结果表明儿童呼吸道感染的主要病原体为PIVS和MP,为临床的合理用药提供参考。

Objective To investigate the epidemiological features of 9 respiratory pathogen Ig M antibody in children with respiratory tract infection in Heyuan,so as to provide reliable basis for efficient clinical prevention and treatment. Methods Sera was collected from 922 children with respiratory tract infections,and indirect immunofluorescence（ IFA） was used to detect the Ig M antibody of 9 main pathogens,including Legionella pneumophila（ LP）,Mycoplasma pneumoniae（ MP）,Q Rickettia（ COX）,Chlamydia pneumonia（ CP）,adenovirus（ ADV）,respiratory syncytial virus（ RSV）,influenza A virus（ IFA）,influenza B virus（ IFB）,parainfluenza virus1,2 and 3（ PIVS）. Results Among 922 infected patients,the positive rate of Ig M antibodies was 29. 39%（ 271/922）,and the dominant pathogens were PIVS（ 14. 21%） and MP（ 14. 10%）,COX was not detected. There were no statistical significance on the differences between different genders（ χ^2= 0. 338,P〉0. 05）. The positive rate of 1 year age group was significantly lower than other group,with the difference statistically significant,but there was no statistical significance on the difference compared with the other two groups. This region is dominated by a single infection,the rate of mixed infection was 7. 16%,among them,mixed infection of MP with PIVS was the most common infection. Conclusion According to the combined detection of 9 pathogen Ig M antibodies,the most common pathogens causing respiratory tract infections in children in Heyuan are PIVS and MP,which can provide reference for clinical rational drug use.