“模板浇铸法”制备明胶微胶囊

Gelatin Microcapsules Fabricated by A“ Template Casting Strategy”

本文通过"模板法浇铸法",制备了大小可控、内部中空、表面多孔的明胶微胶囊。这里以聚丙烯氯化铵(PAH)掺杂的CaCO_3为模板,与未掺杂的碳酸钙相比,PAH掺杂的碳酸钙具有内部致密、表面多孔的性质。当将此模板与热明胶溶液混合吸附,交联除核后,得到具有中空结构的明胶微胶囊。此明胶微胶囊具有良好的生物兼容性及生物可降解性,并且对pH及盐度的改变具有响应性。它的表面带有负电荷,可以有效吸附带有正电荷的药物分子。吸附药物分子后的明胶微球可由盐度来调控药物分子的释放。同时,采用共沉淀技术将药物模型分子FITC-dextran引入到碳酸钙内部,以此模板粒子为模板制备了负载有药物模型分子的明胶微胶囊。本方法具有简单、药物包覆率高、成本低等优势,未来在药物装载与缓释领域具有巨大的应用价值。

Gelatin microcapsules with a hollow structure and porous surface were successfully fabricated by a “template casting strategy” . Herein, we took PAH doped CaC03 as templates which have a porous surface and compacted cores compared to undoped CaC03. Gelatin microcapsule were obtained after incubation of PAH-CaC03 in hot gelatin solution, cross-linked by genipin and removing the sacrificial cores. The gelatin microcapsules have novel physicochemical properties. The microcapsules have a good biocompatibility and biodegradability, and can response to the change of pH and salt concentration. In addition, Model drug FITC-dextran can be incorporated into CaC03 by co-deposition method. The method presented here are certified to be facile, high drug loading efficiency and low cost, having potential application in the drug encapsulation/release field.