PON-1基因多态性与PCI术后主要心血管事件相关性研究

Correlation between PON1 gene polymorphism and major cardiovascular events after PCI

目的:探讨影响经皮冠状动脉介入术(PCI)预后的危险因素,并分析冠状动脉介入术患者PON-1基因多态性与PCI术后主要心血管事件(MACE)的相关性。方法:选取冠状动脉介入术患者362例,采用聚合酶链式反应-限制性片段长度多态性技术(PCR-RFCP)检测各组PON1Q192R基因的多态性,统计分析患者住院期间与术后6个月随访期间患者MACE的发生情况,分析PON1基因Q192R多态性与PCI术后MACE发生的相关性。结果:PON1基因Q192R的多态性与MACE发生无明显相关。结论:PON1基因Q192R的多态性与冠心病患者PCI术后主要心血管事件发生的危险因素无关,但需要更多的研究证实。

Objective： To investigate the risk factors influencing the prognosis of patients with coronary artery intervention, and analyze the correlation between PON-1 gene polymorphism and the major adverse cardiovascular events after PCI.Methods： 362 patients with PCI were selected, PON1 Q192R polymorphism was detected with polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） technology.All the patients were followed up 6 months, the incidence of MACE during the period was monitored and recorded.The correlation between PON1 gene polymorphism and MACE was analyzed.Results：The incidence of MACE after PCI was not significantly correlated with PON1 gene polymorphism.Conclusion：There is no correlation between MACE and PON1 gene polymorphism, but more high quality investigation is in need.