多奈哌齐对阿尔茨海默病患者外周血Aβ1-42和Tau蛋白浓度的影响

Effect of Donepezil on the Concentration of Aβ1-42 and Tau Protein in the Peripheral Blood of Patients with Alzheimer's Disease

目的探讨多奈哌齐对阿尔茨海默病(Alzheimer's disease,AD)患者血浆淀粉样蛋白(β-amyloid peptide1-42,Aβ1-42)和Tau蛋白浓度的影响。方法采用ELISA技术测定48例轻中度AD患者和42例正常对照者血浆Aβ1-42和Tau蛋白浓度,AD组与对照组分别给予多奈哌齐和维生素E口服6个月。结果 AD患者治疗前Aβ1-42蛋白浓度为(41.14±6.28)pg/mL,低于对照组(52.87±10.83)pg/mL(<0.05)。多奈哌齐治疗后Aβ1-42蛋白浓度(47.91±7.47)pg/mL,较治疗前升高(<0.05)。AD患者治疗前Tau蛋白浓度为(22.17±4.93)pg/mL,高于对照组的(18.56±6.21)pg/mL(<0.05),治疗后浓度降低到(20.16±4.24)pg/mL,但差异无统计学意义(>0.05)。结论多奈哌齐增加AD患者血浆Aβ1-42蛋白浓度,可能通过减少A蛋白的沉积来发挥治疗作用。

Objective To discuss the effect of donepezil on the concentration of β-amyloid peptide 1-42 （Aβ1-42））and Tau protein in patients with Alzheimer＇s disease （AD）. Methods ELISA was applied in detecting the concentration ofplasmaAβ1-42 and Tau protein of 48 patients with mild to moderate AD in AD group and 42 norm in control group; oral ad-ministration of both donepezil and vitamin E was performed in all the cases in the 2 groups for 6 months. Results Before treat-ment, the concentration ofAβ1-42 protein of the patients in AD group was （41.14±6.28） pg/mL, lower than that of thecases in control group： （52.87±10.83） pg/mL（P〈0.05）; after the treatment with donepezil, the concentration ofAβ1-42protein of the patients in AD group increased and was higher than that before treatment（P〈0.05）; before treatment, theconcentration of Tau protein of the patients in AD group was （22.17±4.93） pg/mL, higher than that in control group：（18.56±6.21） pg/mL（P〈0.05）; after treatment, the concentration of Tau protein of the patients in AD group decreased to（20.16±4.24） pg/mL, the difference from that before treatment was of no statistical significance（P〉0.05）. ConclusionsDonepezil increases the concentration ofAβ1-42 protein in plasma of AD patients, it may play a therapeutic role by reducing-amyloid peptide’s deposition.