宣威乌头中生物碱成分的研究

Study on the diterpenoid alkaloids from Aconitum nagarumvar lasiandrum

目的研究宣威乌头Aconitum nagarumvar lasiandrum中的生物碱成分。方法采用酸提碱沉法提取总碱、硅胶层析法分离,用波谱法鉴定结构。结果和结论从宣威乌头中分得10个单体化合物,应用光谱法鉴定了其结构为:光翠雀碱(denudatine)、宋果灵(songorine)、delnuttaline等3个C_(20)-二萜生物碱和尼奥灵(neoline)、3-去氧乌头碱(3-deoxyaconitine)、8-methoxy-14-benzoylaconine、伏乌碱(flavaconitine)、异塔拉萨敏(isotalatizidine)、乌头碱(aconitine)和nevadensine等7个C_(19)-二萜生物碱。

OBJECTIVE To investigate the chemical constituents of Aconitum nagarumvar lasiandrum. METHODS Chromatography on silica gel was used to extract and to isolate the alkaloids. RESULTS and CONCLUSION Ten compounds, three C20 - diterpenoid alkaloids and seven C19 - diterpenoid alkaloids, have been isolated. These compounds were confirmed as denudatine, songorine, delnuttaline, neoline, 3 - deoxyaconitine, 8 - methoxy - 14 - benzoylaconine, flavaconitine, isotalatizidine, aconitine and nevadensine by spectral data.