ALOX5AP基因SG13S89多态性与中国人缺血性脑卒中相关性的Meta分析

SG13S89 polymorphism in ALOX5AP and risk of ischemic stroke in Chinese population:a meta-analysis

目的系统评价ALOX5AP基因SG13S89多态性与中国人缺血性脑卒中的相关性。方法计算机检索Web of Science、Pub Med、CNKI、CBM、EMbase和Wan Fang Data数据库,搜集与ALOX5AP基因SG13S89多态性与缺血性脑卒中发生的相关性研究,检索时限均为建库至2016年10月。由2名研究者独立进行文献筛选、资料提取和评价纳入研究的偏倚风险评价后,采用STATA 12.0进行Meta分析。结果共纳入11个病例-对照研究。Meta分析结果显示ALOX5AP基因SG13S89多态性与中国人缺血性脑卒中发病风险增加相关[A vs.G:OR=1.192,95%CI(1.029,1.381),P=0.019;AA+AG vs.GG:OR=1.20,95%CI(1.029,1.400),P=0.020;AG vs.GG:OR=1.195,95%CI(1.022,1.397),P=0.025]。结论 ALOX5AP基因SG13S89多态性与中国人缺血性脑卒中有关,A等位基因是其潜在危险因素。

Objective To systematically review the association between SG13S89 polymorphism in ALOXSAP gene and ischemic stroke in Chinese population. Methods Web of Science, PubMed, CNKI, CBM, EMbase and WanFang Data databases were searched to collect studies about the association between SG13S89 polymorphism in ALOXSAP gene and ischemic stroke from inception to October 2016. Two researchers independently screened literature, extracted data and evaluated the risk of bias of included studies. The meta-analysis was performed by STATA 12.0. Results A total of 11 case-control studies were included. The results of meta-analysis showed that SG13S89 polymorphism in ALOXSAP gene was associated with the risk ofischemic stroke in Chinese （A vs. G： OR=1.192, 95%CI 1.029 to 1.381, P=0.019; AA＋AG vs. GG： OR=1.20, 95%CI 1.029 to 1.400, P=0.020; AG vs. GG： OR=1.195, 95% CI 1.022 to 1.397, P=0.025）. Conclusion SG13S89 polymorphism in ALOX5AP gene may be related to ischemic stroke for Chinese, A allele may be a risk factor.