试验序贯分析检验Cochrane泌尿外科学小组Meta分析假阳性结果的研究

Examining the false-positive results of meta-analysis of Cochrane urology group using trial sequential analysis

目的采用试验序贯分析(TSA)检验Cochrane泌尿外科学小组累积Meta分析假阳性结果。方法计算机检索The Cochrane Library(2016年第6期)"Urology Group"的系统评价,查找具有阳性结果的Meta分析。由2位研究者独立进行文献筛选和资料提取,然后采用TSA 0.9β软件进行TSA。结果共纳入11个Meta分析。TSA结果显示,11个Meta分析中,有8个(72.7%)Meta分析的结论既未穿过TSA界值,也未达到期望信息量,为潜在的假阳性结果。结论 TSA可以辅助判断Meta分析的结果是否为假阳性结果。

Objective To detect the false-positive results of cumulative meta-analyses of Cochrane Urology Group with the trial sequential analysis （TSA）. Methods The systematic reviews of Urology Group of The Cochrane Library were searched to collect meta-analyses with positive results. Two researchers independently screened literature and extracted data of included meta-analyses. Then, TSA was performed using TSA software version 0.9 beta. Results A total of 11 meta-analyses were included. The results of TSA showed that, 8 of 11 （72.7%） meta-analyses were potentially false-positive results for failing to surpass the trial sequential monitoring boundary and to reach the required information size. Conclusion TSA can help researchers to identify the false-positive results ofmeta-analyses.